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Side effect(s) of Amitriptyline and Perphenazine


Review the side-effects of Amitriptyline and Perphenazine as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

   Heart
- High/low blood pressure, slow/fast heart rate, fainting, heart arrest, poor blood circulation, abnormal heart rhythm, lightheadedness, faintness, dizziness, EKG changes and palpitations.

   Central Nervous System
- Sedation, movement disorder, restlessness, rigidity, drowsiness, headache, weakness, anxiety, agitation, mania, exacerbation of psychosis, dizziness, tremor, fatigue, slurring of speech, sleeplessness, vertigo, seizures, abnormalities of CSF proteins, excitement, catatonic-like states, lethargy, hyperactivity and abnormal dreams.

   Skin
- Photosensitivity reaction, pigmentation, dry skin, inflammation, hives, rash, skin disorder, pimples and itching.

   Eye and ENT
- Increased eye pressure, photophobia, nose inflammation, inflammation of pharynx, ringing in the ear, blurred vision, nasal congestion, and dilatation of pupil.

   Gastrointestinal
- Indigestion, intestinal obstruction, constipation, nausea, vomiting, loss of appetite, diarrhea, peculiar taste, dry mouth or throat.

   Genitourinary
- Urinary retention, impotence, sexual dysfunction, menstrual irregularities and night time urination.

   Blood
- Abnormal decrease in white blood cells, eosinophilia, anemia, bruising and decrease in platelets.

   Liver
- Jaundice.

   Metabolic
- Increase or decrease in blood sugar.

   Respiratory
- Asthma, difficulty in breathing and cough.

   Miscellaneous
- Increased appetite, weight and thirst, breast enlargement in males and milk secretion in women.

Other Precautions :

Patient may develop with involuntary muscle movements; if it so consult with your doctor immediately.

Drug Name : Amitriptyline and Perphenazine

Amitriptyline and Perphenazine(Duo-Vil 2-10) generic is a phenothiazine and tricyclic antidepressant combination, prescribed for anxiety and depression. Serotonin and noradrenaline reabsorption prevent by Amitriptyline where as Perphenazine blocks a variety of receptors in the brain.


Trade Names for Amitriptyline and Perphenazine

International :


Duo-Vil 2-10, Etrafon, Triavil, PMS-Levazine, Triptazine.

Note: Brand is not available in US market
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