Tegafur, gimeracil, and oteracil combination is available in a capsule form which should be taken by mouth twice daily (morning and evening) at least one hour before or one hour after meals.
The capsule should not be broken, opened, crushed or chewed because it may affect the healthy cells when it comes into contact as it is a cytotoxic agent.
Swallow the capsule of tegafur, gimeracil, and oteracil with sufficient quantity of water.
If the patient vomits after taking the dose of tegafur, gimeracil, and oteracil do not repeat the dose but take the next dose on the following day as directed.
The recommended dose of tegafur, gimeracil, and oteracil is 25 mg/m2 given for 21 consecutive days followed by seven treatment-free days in a 28-day treatment cycle repeated every four weeks.
The dose of cisplatin is 75 mg/m2 given once every four weeks and discontinued after six continuous cycles. If cisplatin therapy is discontinued before 6 cycles, treatment with tegafur, gimeracil, and oteracil alone can be started as per the prescribed schedule.
Dose modification of tegafur, gimeracil, and oteracil or cisplatin can be considered if patients develop toxicity while making sure the dose that is omitted is not replaced.
The dose of tegafur, gimeracil, and oteracil that is reduced due to toxicity reasons should not be increased to the usual dose but can be resumed at one reduced dose level.
• If there is an allergy to tegafur, gimeracil and oteracil combination
• Allergic to cisplatin or fluoropyrimidine group of drugs (e.g., Capecitabine, Fluorouracil, Doxifluridine)
• Pregnancy and breastfeeding
• Severe bone marrow suppression
• History of dihydropyrimidine dehydrogenase (DPD) deficiency
• Undergoing dialysis in end-stage kidney disease
• Children below 18 years of age
Never take a double dose of tegafur, gimeracil, and oteracil capsules to make up for the missed dose which can be harmful.
The capsule should not be broken, opened, crushed or chewed because it may affect the healthy cells when it comes into contact as it is a cytotoxic agent.
Swallow the capsule of tegafur, gimeracil, and oteracil with sufficient quantity of water.
If the patient vomits after taking the dose of tegafur, gimeracil, and oteracil do not repeat the dose but take the next dose on the following day as directed.
Dosage & When it is to be taken
The dose of tegafur, gimeracil, and oteracil along with cisplatin is calculated based on the individual patient’s body surface area (BSA) depending on the height and the weight of the patient.The recommended dose of tegafur, gimeracil, and oteracil is 25 mg/m2 given for 21 consecutive days followed by seven treatment-free days in a 28-day treatment cycle repeated every four weeks.
The dose of cisplatin is 75 mg/m2 given once every four weeks and discontinued after six continuous cycles. If cisplatin therapy is discontinued before 6 cycles, treatment with tegafur, gimeracil, and oteracil alone can be started as per the prescribed schedule.
Dose modification of tegafur, gimeracil, and oteracil or cisplatin can be considered if patients develop toxicity while making sure the dose that is omitted is not replaced.
The dose of tegafur, gimeracil, and oteracil that is reduced due to toxicity reasons should not be increased to the usual dose but can be resumed at one reduced dose level.
When it is not to be taken (Contraindications)
Tegafur, gimeracil and oteracil combination should not be used in patients-• If there is an allergy to tegafur, gimeracil and oteracil combination
• Allergic to cisplatin or fluoropyrimidine group of drugs (e.g., Capecitabine, Fluorouracil, Doxifluridine)
• Pregnancy and breastfeeding
• Severe bone marrow suppression
• History of dihydropyrimidine dehydrogenase (DPD) deficiency
• Undergoing dialysis in end-stage kidney disease
• Children below 18 years of age
What if you Miss a Dose of Tegafur, Gimeracil, Oteracil?
If a dose of tegafur, gimeracil, and oteracil is missed do not take the missed dose but continue with the next following dose.Never take a double dose of tegafur, gimeracil, and oteracil capsules to make up for the missed dose which can be harmful.
