Sofosbuvir is available in the form of tablets which should be taken by mouth either with or without food.
Take the tablets of sofosbuvir at the same time every day.
Do not break, crush, or chew the sofosbuvir tablets but swallow the tablet as a whole with sufficient quantity of water.
Take another tablet if vomiting occurs within 2 hours of taking a sofosbuvir tablet but do not take an additional dose of sofosbuvir if vomiting occurs after 2 hours of taking the tablet.
The dose of ribavirin and peginterferon alfa is decided based on the following parameters-
• Body weight of the patient
• Health status of the kidneys
• Side effects
The recommended drug combination and treatment duration for treating patients with HCV infection and HCV/HIV-1 co-infection are as follows:
Sofosbuvir, peginterferon alfa, and ribavirin should be used in patients with genotype 1 or 4 CHC for up to 12 weeks.
The combination of sofosbuvir and ribavirin is used for the duration of 12 weeks in patients with genotype 2 CHC and for 24 weeks in patients with genotype 3 CHC.
Patients with liver cancer waiting for liver transplantation must be treated with sofosbuvir and ribavirin for at least 48 weeks or until the time of liver transplantation to prevent post-transplant HCV re-infection.
Dose reduction of sofosbuvir is not recommended but the dose of ribavirin or peginterferon alfa can be altered or decreased depending on the severity of the side effects.
• If there is an allergy to sofosbuvir, ribavirin or peginterferon alfa
• Children less than 12 years of age
• Pregnancy and breastfeeding
• Hepatitis B infection
Using sofosbuvir as a single agent in treating chronic hepatitis C is not recommended.
If the timing is more than 18 hours from the missed dose, avoid the missed dose and take the next dose as per the following schedule.
Avoid taking a double dose of sofosbuvir to make up for the missed dose which can result in harm.
Take the tablets of sofosbuvir at the same time every day.
Do not break, crush, or chew the sofosbuvir tablets but swallow the tablet as a whole with sufficient quantity of water.
Take another tablet if vomiting occurs within 2 hours of taking a sofosbuvir tablet but do not take an additional dose of sofosbuvir if vomiting occurs after 2 hours of taking the tablet.
Dosage & When it is to be taken
The recommended dose of sofosbuvirin adults is 400 mg to be taken once daily.The dose of ribavirin and peginterferon alfa is decided based on the following parameters-
• Body weight of the patient
• Health status of the kidneys
• Side effects
The recommended drug combination and treatment duration for treating patients with HCV infection and HCV/HIV-1 co-infection are as follows:
Sofosbuvir, peginterferon alfa, and ribavirin should be used in patients with genotype 1 or 4 CHC for up to 12 weeks.
The combination of sofosbuvir and ribavirin is used for the duration of 12 weeks in patients with genotype 2 CHC and for 24 weeks in patients with genotype 3 CHC.
Patients with liver cancer waiting for liver transplantation must be treated with sofosbuvir and ribavirin for at least 48 weeks or until the time of liver transplantation to prevent post-transplant HCV re-infection.
Dose reduction of sofosbuvir is not recommended but the dose of ribavirin or peginterferon alfa can be altered or decreased depending on the severity of the side effects.
When it is not to be taken (Contraindications)
Sofosbuvir should not be used in patients-• If there is an allergy to sofosbuvir, ribavirin or peginterferon alfa
• Children less than 12 years of age
• Pregnancy and breastfeeding
• Hepatitis B infection
Using sofosbuvir as a single agent in treating chronic hepatitis C is not recommended.
What if you Miss a Dose of Sofosbuvir?
The missed dose of sofosbuvir can be taken if the time is within 18 hours from the missed dose timing.If the timing is more than 18 hours from the missed dose, avoid the missed dose and take the next dose as per the following schedule.
Avoid taking a double dose of sofosbuvir to make up for the missed dose which can result in harm.
