Aceclofenac
The serum concentration of Methotrexate can be increased when it is combined with Aceclofenac.
Acemetacin
The serum concentration of Methotrexate can be increased when it is combined with Acemetacin.
Acetyl salicylate
The serum concentration of Methotrexate can be increased when it is combined with Acetylsalicylic acid.
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Acetyldigitoxin
Acetyldigitoxin may decrease the cardiotoxic activities of Methotrexate.
Acitretin
Acitretin may increase the hepatotoxic activities of Methotrexate.
Adapalene
The serum concentration of Methotrexate can be increased when it is combined with Adapalene.
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Alitretinoin
Alitretinoin may increase the hepatotoxic activities of Methotrexate.
Alminoprofen
The serum concentration of Methotrexate can be increased when it is combined with Alminoprofen.
Aloxiprin
The serum concentration of Methotrexate can be increased when it is combined with Aloxiprin.
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AMBROXOL ACEFYLLINATE
The serum concentration of Ambroxol acefyllinate can be increased when it is combined with Methotrexate.
Ambroxol-Theophylline-7-Acetate
The serum concentration of Ambroxol acefyllinate can be increased when it is combined with Methotrexate.
Amdinocillin
The serum concentration of Methotrexate can be increased when it is combined with Amdinocillin.
Amdinocillin Pivoxil
The serum concentration of Methotrexate can be increased when it is combined with Pivmecillinam.
Aminophylline
The serum concentration of Aminophylline can be increased when it is combined with Methotrexate.
Aminosalicylic Acid
The serum concentration of Methotrexate can be increased when it is combined with Aminosalicylic Acid.
Amoxicillin
The serum concentration of Methotrexate can be increased when it is combined with Amoxicillin.
Amoxicillin Anhydrous
The serum concentration of Methotrexate can be increased when it is combined with Amoxicillin.
Ampicillin
The serum concentration of Methotrexate can be increased when it is combined with Ampicillin.
Ampicillin (anhydrous)
The serum concentration of Methotrexate can be increased when it is combined with Ampicillin.
Ancestim
The risk or severity of cytotoxicity can be increased when Ancestim is combined with Methotrexate.
Anhydrous Tacrolimus
Tacrolimus may increase the immunosuppressive activities of Methotrexate.
Anthrax immune globulin, human
The risk or severity of adverse effects can be increased when Methotrexate is combined with Anthrax immune globulin human.
Antipyrine
The serum concentration of Methotrexate can be increased when it is combined with Antipyrine.
Apalutamide
The serum concentration of Methotrexate can be decreased when it is combined with Apalutamide.
Apazone
The serum concentration of Methotrexate can be increased when it is combined with Azapropazone.
Apremilast
The serum concentration of Methotrexate can be increased when it is combined with Apremilast.
Aspirin
The serum concentration of Methotrexate can be increased when it is combined with Acetylsalicylic acid.
Azelastine
The serum concentration of Methotrexate can be increased when it is combined with Azelastine.
Azidocillin
The serum concentration of Methotrexate can be increased when it is combined with Azidocillin.
Azlocillin
The serum concentration of Methotrexate can be increased when it is combined with Azlocillin.
Azosemide
The therapeutic efficacy of Azosemide can be decreased when used in combination with Methotrexate.
Bacampicillin
The serum concentration of Methotrexate can be increased when it is combined with Bacampicillin.
Balsalazide
The serum concentration of Methotrexate can be increased when it is combined with Balsalazide.
BCG Vaccine
The risk or severity of adverse effects can be increased when Methotrexate is combined with BCG vaccine.
BCG, Live, Connaught Strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Bacillus calmette-guerin substrain connaught live antigen.
BCG, Live, Tice Strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Bacillus calmette-guerin substrain tice live antigen.
Benzydamine
The serum concentration of Methotrexate can be increased when it is combined with Benzydamine.
Benzylpenicilloyl polylysine
The serum concentration of Methotrexate can be increased when it is combined with Benzylpenicilloyl Polylysine.
Bevacizumab
Bevacizumab may increase the cardiotoxic activities of Methotrexate.
Bevacizumab-Awwb
Bevacizumab may increase the cardiotoxic activities of Methotrexate.
Bromfenac
The serum concentration of Methotrexate can be increased when it is combined with Bromfenac.
Bufexamac
The serum concentration of Methotrexate can be increased when it is combined with Bufexamac.
Bumetanide
The therapeutic efficacy of Bumetanide can be decreased when used in combination with Methotrexate.
Cabazitaxel
The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Methotrexate.
Carbenicillin
The serum concentration of Methotrexate can be increased when it is combined with Carbenicillin.
Carprofen
The serum concentration of Methotrexate can be increased when it is combined with Carprofen.
Celecoxib
The serum concentration of Methotrexate can be increased when it is combined with Celecoxib.
Chloroquine
The serum concentration of Methotrexate can be increased when it is combined with Chloroquine.
Chlorthalidone
The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Methotrexate.
Cholestyramine Resin
Cholestyramine can cause a decrease in the absorption of Methotrexate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Choline Magnesium Trisalicyclate
The serum concentration of Methotrexate can be increased when it is combined with Choline magnesium trisalicylate.
Ciprofloxacin
The serum concentration of Methotrexate can be increased when it is combined with Ciprofloxacin.
Clofezone
The serum concentration of Methotrexate can be increased when it is combined with Rabeprazole.
Clonixin
The serum concentration of Methotrexate can be increased when it is combined with Clonixin.
Cloxacillin
The serum concentration of Methotrexate can be increased when it is combined with Cloxacillin.
Clozapine
The risk or severity of adverse effects can be increased when Methotrexate is combined with Clozapine.
Colesevelam
Colesevelam can cause a decrease in the absorption of Methotrexate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colestipol
Colestipol can cause a decrease in the absorption of Methotrexate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Curcumin
The serum concentration of Methotrexate can be increased when it is combined with Curcumin.
Cyclacillin
The serum concentration of Methotrexate can be increased when it is combined with Cyclacillin.
Cyclophosphamide
Cyclophosphamide may increase the cardiotoxic activities of Methotrexate.
Cyclophosphamide Anhydrous
Cyclophosphamide may increase the cardiotoxic activities of Methotrexate.
Cyclosporine
The serum concentration of Methotrexate can be increased when it is combined with Cyclosporine.
Denosumab
The risk or severity of adverse effects can be increased when Denosumab is combined with Methotrexate.
Deslanoside
Deslanoside may decrease the cardiotoxic activities of Methotrexate.
Dexketoprofen
The serum concentration of Methotrexate can be increased when it is combined with Dexketoprofen.
Dexlansoprazole
The serum concentration of Methotrexate can be increased when it is combined with Dexlansoprazole.
Diclofenac
The serum concentration of Methotrexate can be increased when it is combined with Diclofenac.
Dicloxacillin
The serum concentration of Methotrexate can be increased when it is combined with Dicloxacillin.
Diflunisal
The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Digitoxin
Digitoxin may decrease the cardiotoxic activities of Methotrexate.
Digoxin
Digoxin may decrease the cardiotoxic activities of Methotrexate.
Dipyrone
The risk or severity of adverse effects can be increased when Methotrexate is combined with Metamizole.
Docetaxel
The risk or severity of adverse effects can be increased when Docetaxel is combined with Methotrexate.
DOCETAXEL ANHYDROUS
The risk or severity of adverse effects can be increased when Docetaxel is combined with Methotrexate.
Droxicam
The serum concentration of Methotrexate can be increased when it is combined with Droxicam.
Dyphylline
The serum concentration of Dyphylline can be increased when it is combined with Methotrexate.
Eltrombopag
The serum concentration of Methotrexate can be increased when it is combined with Eltrombopag.
Esomeprazole
The serum concentration of Methotrexate can be increased when it is combined with Esomeprazole.
Etanercept
The serum concentration of Methotrexate can be increased when it is combined with Etanercept.
Ethacrynate
The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Methotrexate.
Ethacrynic Acid
The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Methotrexate.
Etodolac
The serum concentration of Methotrexate can be increased when it is combined with Etodolac.
Etofenamate
The serum concentration of Methotrexate can be increased when it is combined with Etofenamate.
Etoricoxib
The serum concentration of Methotrexate can be increased when it is combined with Etoricoxib.
Evening primrose oil
The serum concentration of Methotrexate can be increased when it is combined with Evening primrose oil.
Felbinac
The serum concentration of Methotrexate can be increased when it is combined with Felbinac.
Fenbufen
The serum concentration of Methotrexate can be increased when it is combined with Fenbufen.
Fenoprofen
The serum concentration of Methotrexate can be increased when it is combined with Fenoprofen.
Ferulic Acid
The serum concentration of Methotrexate can be increased when it is combined with Ferulic acid.
Fingolimod
Methotrexate may increase the immunosuppressive activities of Fingolimod.
Floctafenine
The serum concentration of Methotrexate can be increased when it is combined with Floctafenine.
Floxacillin
The serum concentration of Methotrexate can be increased when it is combined with Flucloxacillin.
Flurbiprofen
The serum concentration of Methotrexate can be increased when it is combined with Flurbiprofen.
Foscarnet
Foscarnet may increase the nephrotoxic activities of Methotrexate.
Fosphenytoin
The serum concentration of Fosphenytoin can be decreased when it is combined with Methotrexate.
Furosemide
The therapeutic efficacy of Furosemide can be decreased when used in combination with Methotrexate.
Hepatitis A Vaccine, Inactivated
The risk or severity of adverse effects can be increased when Methotrexate is combined with Hepatitis A Vaccine.
Hepatitis B Surface Antigen Vaccine
The risk or severity of adverse effects can be increased when Methotrexate is combined with Hepatitis B Vaccine (Recombinant).
Hydroflumethiazide
The therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Methotrexate.
Ibuprofen
The serum concentration of Methotrexate can be increased when it is combined with Ibuprofen.
Icatibant
The serum concentration of Methotrexate can be increased when it is combined with Icatibant.
Indobufen
The serum concentration of Methotrexate can be increased when it is combined with Indobufen.
Indomethacin
The serum concentration of Methotrexate can be increased when it is combined with Indomethacin.
Isavuconazole
The serum concentration of Methotrexate can be increased when it is combined with Isavuconazole.
Kebuzone
The serum concentration of Methotrexate can be increased when it is combined with Kebuzone.
Ketoprofen
The serum concentration of Methotrexate can be increased when it is combined with Ketoprofen.
Ketorolac
The serum concentration of Methotrexate can be increased when it is combined with Ketorolac.
Lansoprazole
The serum concentration of Methotrexate can be increased when it is combined with Lansoprazole.
Leflunomide
The risk or severity of adverse effects can be increased when Methotrexate is combined with Leflunomide.
Levetiracetam
Levetiracetam may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Limonene, (+)-
The serum concentration of Methotrexate can be increased when it is combined with (4R)-limonene.
Lipegfilgrastim
Methotrexate may increase the myelosuppressive activities of Lipegfilgrastim.
Lornoxicam
The serum concentration of Methotrexate can be increased when it is combined with Lornoxicam.
Loxoprofen
The serum concentration of Methotrexate can be increased when it is combined with Loxoprofen.
Lumacaftor
The serum concentration of Methotrexate can be decreased when it is combined with Lumacaftor.
Magnesium Salicylate
The serum concentration of Methotrexate can be increased when it is combined with Magnesium salicylate.
Masoprocol
The serum concentration of Methotrexate can be increased when it is combined with Masoprocol.
Meclofenamate
The serum concentration of Methotrexate can be increased when it is combined with Meclofenamic acid.
Meclofenamic Acid
The serum concentration of Methotrexate can be increased when it is combined with Meclofenamic acid.
Mefenamic Acid
The serum concentration of Methotrexate can be increased when it is combined with Mefenamic acid.
Meloxicam
The serum concentration of Methotrexate can be increased when it is combined with Meloxicam.
Mesalamine
The serum concentration of Methotrexate can be increased when it is combined with Mesalazine.
Methampicillin
The serum concentration of Methotrexate can be increased when it is combined with Metampicillin.
Methyclothiazide
The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Methotrexate.
Methyl Salicylate
The serum concentration of Methotrexate can be increased when it is combined with Methyl salicylate.
Mezlocillin
The serum concentration of Methotrexate can be increased when it is combined with Mezlocillin.
Mipomersen
Mipomersen may increase the hepatotoxic activities of Methotrexate.
MYCOPHENOLATE
The serum concentration of Methotrexate can be increased when it is combined with Mycophenolic acid.
Mycophenolate Mofetil
The serum concentration of Methotrexate can be increased when it is combined with Mycophenolate mofetil.
Mycophenolic Acid
The serum concentration of Methotrexate can be increased when it is combined with Mycophenolic acid.
Nabumetone
The serum concentration of Methotrexate can be increased when it is combined with Nabumetone.
Nafcillin
The serum concentration of Methotrexate can be increased when it is combined with Nafcillin.
Naftifine
The serum concentration of Methotrexate can be increased when it is combined with Naftifine.
Naproxen
The serum concentration of Methotrexate can be increased when it is combined with Naproxen.
Natalizumab
The risk or severity of adverse effects can be increased when Methotrexate is combined with Natalizumab.
Nepafenac
The serum concentration of Methotrexate can be increased when it is combined with Nepafenac.
Niflumic Acid
The serum concentration of Methotrexate can be increased when it is combined with Niflumic Acid.
Nimesulide
The serum concentration of Methotrexate can be increased when it is combined with Nimesulide.
Ocrelizumab
Ocrelizumab may increase the immunosuppressive activities of Methotrexate.
Oenothera biennis seed extract
The serum concentration of Methotrexate can be increased when it is combined with Evening primrose oil.
Olopatadine
The serum concentration of Methotrexate can be increased when it is combined with Olopatadine.
Olsalazine
The serum concentration of Methotrexate can be increased when it is combined with Olsalazine.
Omeprazole
The serum concentration of Methotrexate can be increased when it is combined with Omeprazole.
Ouabain
Ouabain may decrease the cardiotoxic activities of Methotrexate.
Ovine Digoxin Immune Fab
Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Methotrexate.
Oxacillin
The serum concentration of Methotrexate can be increased when it is combined with Oxacillin.
Oxaprozin
The serum concentration of Methotrexate can be increased when it is combined with Oxaprozin.
Oxyphenbutazone
The serum concentration of Methotrexate can be increased when it is combined with Oxyphenbutazone.
Paclitaxel
The risk or severity of adverse effects can be increased when Paclitaxel is combined with Methotrexate.
Palmidrol
The serum concentration of Methotrexate can be increased when it is combined with Palmidrol.
Pantoprazole
The serum concentration of Methotrexate can be increased when it is combined with Pantoprazole.
Parecoxib
The serum concentration of Methotrexate can be increased when it is combined with Parecoxib.
Parthenolide
The serum concentration of Methotrexate can be increased when it is combined with Parthenolide.
Penicillin G
The serum concentration of Methotrexate can be increased when it is combined with Benzylpenicillin.
penicillin G benzathine
The serum concentration of Methotrexate can be increased when it is combined with Benzathine benzylpenicillin.
penicillin G procaine
The serum concentration of Methotrexate can be increased when it is combined with Procaine benzylpenicillin.
Penicillin V
The serum concentration of Methotrexate can be increased when it is combined with Phenoxymethylpenicillin.
Phenylbutazone
The serum concentration of Methotrexate can be increased when it is combined with Phenylbutazone.
Phenytoin
The serum concentration of Phenytoin can be decreased when it is combined with Methotrexate.
Pimecrolimus
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Methotrexate.
Piperacillin
The serum concentration of Methotrexate can be increased when it is combined with Piperacillin.
Piperacillin Anhydrous
The serum concentration of Methotrexate can be increased when it is combined with Piperacillin.
Piretanide
The therapeutic efficacy of Piretanide can be decreased when used in combination with Methotrexate.
Pirfenidone
The serum concentration of Methotrexate can be increased when it is combined with Pirfenidone.
Piroxicam
The serum concentration of Methotrexate can be increased when it is combined with Piroxicam.
Piroxicam-Beta-Cyclodextrin
The serum concentration of Methotrexate can be increased when it is combined with Piroxicam.
Pivampicillin
The serum concentration of Methotrexate can be increased when it is combined with Pivampicillin.
Probenecid
The serum concentration of Methotrexate can be increased when it is combined with Probenecid.
Propicillin
The serum concentration of Methotrexate can be increased when it is combined with Propicillin.
Proscillaridin
Proscillaridin may decrease the cardiotoxic activities of Methotrexate.
Quinethazone
The therapeutic efficacy of Quinethazone can be decreased when used in combination with Methotrexate.
Rabeprazole
The serum concentration of Methotrexate can be increased when it is combined with Rabeprazole.
Rabies Immune Globulin, Human
The risk or severity of adverse effects can be increased when Methotrexate is combined with Human rabies virus immune globulin.
Rabies Virus Vaccine Flury-Lep Strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Rabies virus inactivated antigen, A.
Ranolazine
The serum concentration of Methotrexate can be increased when it is combined with Ranolazine.
Resveratrol
The serum concentration of Methotrexate can be increased when it is combined with Resveratrol.
Rofecoxib
The serum concentration of Methotrexate can be increased when it is combined with Rofecoxib.
Roflumilast
Roflumilast may increase the immunosuppressive activities of Methotrexate.
Rolapitant
The serum concentration of Methotrexate can be increased when it is combined with Rolapitant.
ROTAVIRUS VACCINE, LIVE
The risk or severity of adverse effects can be increased when Methotrexate is combined with Rotavirus Vaccine.
Rubella Virus Vaccine Live (wistar Ra 27-3 Strain)
The risk or severity of adverse effects can be increased when Methotrexate is combined with Rubella virus vaccine.
Salicylamide
The serum concentration of Methotrexate can be increased when it is combined with Salicylamide.
Salicylic Acid
The serum concentration of Methotrexate can be increased when it is combined with Salicylic acid.
Salmonella enterica subsp. enterica serovar typhi
The risk or severity of adverse effects can be increased when Methotrexate is combined with Salmonella typhi ty21a live antigen.
Salsalate
The serum concentration of Methotrexate can be increased when it is combined with Salsalate.
Sapropterin
The serum concentration of Sapropterin can be decreased when it is combined with Methotrexate.
Sarilumab
Sarilumab may increase the immunosuppressive activities of Methotrexate.
Serratiopeptidase
The serum concentration of Methotrexate can be increased when it is combined with Serrapeptase.
sipuleucel-T
The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Methotrexate.
Sulbactam
The serum concentration of Methotrexate can be increased when it is combined with Sulbactam.
Sulfadiazine
The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Methotrexate.
Sulfamethoxazole
The risk or severity of adverse effects can be increased when Sulfamethoxazole is combined with Methotrexate.
Sulfasalazine
Sulfasalazine may increase the hepatotoxic activities of Methotrexate.
Sulfisoxazole
The risk or severity of adverse effects can be increased when Sulfisoxazole is combined with Methotrexate.
Sulindac
The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Suprofen
The serum concentration of Methotrexate can be increased when it is combined with Suprofen.
Tacrolimus
Tacrolimus may increase the immunosuppressive activities of Methotrexate.
Tazobactam
The serum concentration of Methotrexate can be increased when it is combined with Tazobactam.
Tegafur
The risk or severity of adverse effects can be increased when Methotrexate is combined with Tegafur.
Tenoxicam
The serum concentration of Methotrexate can be increased when it is combined with Tenoxicam.
Teriflunomide
The serum concentration of Methotrexate can be increased when it is combined with Teriflunomide.
Tetanus Toxoid Vaccine, Inactivated
The risk or severity of adverse effects can be increased when Methotrexate is combined with Clostridium tetani toxoid antigen (formaldehyde inactivated).
Theophylline
The serum concentration of Theophylline can be increased when it is combined with Methotrexate.
Theophylline anhydrous
The serum concentration of Theophylline can be increased when it is combined with Methotrexate.
Tiaprofenic Acid
The serum concentration of Methotrexate can be increased when it is combined with Tiaprofenic acid.
Ticarcillin
The serum concentration of Methotrexate can be increased when it is combined with Ticarcillin.
Tofacitinib
Methotrexate may increase the immunosuppressive activities of Tofacitinib.
Tolfenamic Acid
The serum concentration of Methotrexate can be increased when it is combined with Tolfenamic Acid.
Tolmetin
The serum concentration of Methotrexate can be increased when it is combined with Tolmetin.
Torsemide
The therapeutic efficacy of Torasemide can be decreased when used in combination with Methotrexate.
Tranilast
The serum concentration of Methotrexate can be increased when it is combined with Tranilast.
Trastuzumab
Trastuzumab may increase the cardiotoxic activities of Methotrexate.
Tribenoside
The serum concentration of Methotrexate can be increased when it is combined with Tribenoside.
Trichlormethiazide
The therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Methotrexate.
Trimethoprim
The risk or severity of adverse effects can be increased when Trimethoprim is combined with Methotrexate.
Trolamine Salicylate
The serum concentration of Methotrexate can be increased when it is combined with Trolamine salicylate.
Typhoid Vaccine Live Ty21a
The risk or severity of adverse effects can be increased when Methotrexate is combined with Salmonella typhi ty21a live antigen.
Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Salmonella typhi ty2 vi polysaccharide antigen.
Valdecoxib
The serum concentration of Methotrexate can be increased when it is combined with Valdecoxib.
Varicella Virus Vaccine Live (Oka-Merck) strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Varicella Zoster Vaccine (Live/Attenuated).
Vemurafenib
The serum concentration of Methotrexate can be increased when it is combined with Vemurafenib.
Yellow Fever Vaccine
The risk or severity of adverse effects can be increased when Methotrexate is combined with Yellow Fever Vaccine.
Yellow-Fever Virus Vaccine, 17D-204 strain
The risk or severity of adverse effects can be increased when Methotrexate is combined with Yellow Fever Vaccine.
Zileuton
The serum concentration of Methotrexate can be increased when it is combined with Zileuton.
Zomepirac
The serum concentration of Methotrexate can be increased when it is combined with Zomepirac.
