Are you taking Clomipramine? Are you aware of the dangers of combining Clomipramine with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Vandel P, Regina W, Reix I, Vandel S, Sechter D, Bizouard P. Faut-il contre-indiquer le jus de pamplemousse? Une approche en psychiatrie [Grapefruit juice as a contraindication? An approach in psychiatry]. Encephale. 1999 Jan-Feb;25(1):67-71. French.
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Tobacco: Avoid using tobacco while taking Clomipramine as it may reduce the exposure of CYP1A2 substrates (2✔ ✔Trusted Source
De Jong C, Drubbel I, Roelfs S, Harmsze A. Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking. J Clin Psychopharmacol. 2018 Aug;38(4):389-391.
Go to source).
National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines.
Go to source).
References
1. Vandel P, Regina W, Reix I, Vandel S, Sechter D, Bizouard P. Faut-il contre-indiquer le jus de pamplemousse? Une approche en psychiatrie [Grapefruit juice as a contraindication? An approach in psychiatry]. Encephale. 1999 Jan-Feb;25 (1):67-71. French. PMID: 10205736.
2. De Jong C, Drubbel I, Roelfs S, Harmsze A. Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking. J Clin Psychopharmacol. 2018 Aug;38 (4):389-391. doi: 10.1097/JCP.0000000000000896. PMID: 29894392.
3. National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
4. National Library of Medicine: Clomipramine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a697002.html#
Clomipramine Interactions with Food and Herbs
Grapefruit: Grapefruit juice with Clomipramine interaction may raise the risk of drug toxicity (1✔ ✔Trusted SourceVandel P, Regina W, Reix I, Vandel S, Sechter D, Bizouard P. Faut-il contre-indiquer le jus de pamplemousse? Une approche en psychiatrie [Grapefruit juice as a contraindication? An approach in psychiatry]. Encephale. 1999 Jan-Feb;25(1):67-71. French.
Go to source).
Tobacco: Avoid using tobacco while taking Clomipramine as it may reduce the exposure of CYP1A2 substrates (2✔ ✔Trusted Source
De Jong C, Drubbel I, Roelfs S, Harmsze A. Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking. J Clin Psychopharmacol. 2018 Aug;38(4):389-391.
Go to source).
Clomipramine Interactions with Alcohol
Clomipramine should be avoided when taking alcohol since it can cause drowsiness, dizziness, increased risk of overdose, increased depressive symptoms and motor skill impairment (3✔ ✔Trusted SourceNational Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines.
Go to source).
When and How to Take Clomipramine
- Clomipramine is available in the form of a capsule to be taken orally.
- Clomipramine is often taken with meals three times a day. Following a few weeks of therapy, it is typically taken just once a day at bedtime.
- Take the medication at the same time every day for better results.
- Follow the instructions as given by the doctor's prescription.
- Do not exceed or skip a dose. If a dose is missed, take the medication as soon as it is remembered.
- If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule.
- Do not double the dose at a time to compensate for a missed dose.
- Withdrawal symptoms: If taking this medication is suddenly stopped, withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever and irritability may occur (4✔ ✔Trusted Source
National Library of Medicine: Clomipramine MedlinePlus Drug Information.
Go to source).
References
1. Vandel P, Regina W, Reix I, Vandel S, Sechter D, Bizouard P. Faut-il contre-indiquer le jus de pamplemousse? Une approche en psychiatrie [Grapefruit juice as a contraindication? An approach in psychiatry]. Encephale. 1999 Jan-Feb;25 (1):67-71. French. PMID: 10205736.
2. De Jong C, Drubbel I, Roelfs S, Harmsze A. Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking. J Clin Psychopharmacol. 2018 Aug;38 (4):389-391. doi: 10.1097/JCP.0000000000000896. PMID: 29894392.
3. National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
4. National Library of Medicine: Clomipramine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a697002.html#
