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Drug information on Lenerve (250 mg) (Levetiracetam) from East West Pharma

Lenerve (250 mg)   Tablet   East West Pharma Generic : Levetiracetam	89.10 250mg 10 Tablets

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Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)

Further Checked by The Medindia Medical Review Team on February, 2, 2017

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Convulsions

Epilepsy

Juvenile Myoclonic Epilepsy

Tuberous Sclerosis

•  Central Nervous System: Drowsiness, weakness, headache, hostility, fatigue, nervousness, dizziness, personality disorder, irritability, agitation, emotional lability, depression, mood swings, vertigo, anxiety, unsteadiness, seizures, memory loss, confusion, increased reflexes, tingling, aggression and suicidal behavior.

•  Skin: Itching, skin discoloration, rash and loss of hair.

•  Eye and ENT: Inflammation of nasopharynx, stuffy nose, inflammation of conjunctiva, blurred vision, double vision and ear pain.

•  Gastrointestinal: Vomiting, loss of appetite, diarrhea, nausea, gastroenteritis, constipation and inflammation of pancreas.

•  Genitourinary: Albumin in urine and urine abnormality.

•  Blood: Easy bruising, deficiency of all three blood cell types (with bone marrow suppression in some cases).

•  Liver: Abnormal LFTs (liver function test), liver failure and inflammation.

•  Metabolic: Dehydration and weight loss.

•  Musculoskeletal: Neck pain.

•  Respiratory: Increased cough, asthma and sinusitis.

•  Miscellaneous:Accidental injury, infection, influenza, pain, flu syndrome, face edema and viral infection.

PO/IV- Adjunct in partial seizures- Initial: 500 mg twice daily on the 1st day, may increase gradually. Max: 3 g/day.
Monotherapy for partial seizures with or without secondary generalization- Initial: 500 mg/day, may increase gradually. Max: 3 g/day.

May be taken with or without food. (Oral solution should be diluted in a glass of water.) Administer IV levetiracetam as 15-min infusion following dilution in 100 ml of a compatible diluent.

Hypersensitivity.

• Caution should be exercised in patients with history of liver or kidney problems, allergic reactions, patients undergoing haemodialysis, pregnancy and breastfeeding.

• Patient may develop mood changes, suicidal thoughts.

• It may impair ability to drive or operate machinery during initial therapy.

Do not change the dosage.

Intravenous: Once reconstituted store at 15-30°C and use within 24 hr. Store tablets, oral solution, and undiluted IV injection at 15-30°C.