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Vortioxetine - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on Mar 24, 2014
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Information about Vortioxetine

Generic Name : Vortioxetine
Pronunciation : vor-tye-OX-e-teen
Latest prescription information about Vortioxetine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Vortioxetine

International- Brintellix
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Why is Vortioxetine Prescribed? (Indications)

This medication is an antidepressant used for the treatment of major depressive disorder (MDD) in adults and also investigated as a treatment for generalized anxiety disorder (GAD). 
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When should Vortioxetine not be taken? (Contraindications)

Hypersensitivity to vortioxetine or any components of the formulation. Angioedema has been reported in patients treated with brintellix.

What is the dosage of Vortioxetine?

The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated, because higher doses demonstrated better treatment effects in trials conducted in the United States.

How should Vortioxetine be taken?

This medication is available as immediate-release, film-coated tablets to take by mouth, with or without food. It is available in 5 mg, 10 mg and 20 mg tablets.

What are the warnings and precautions for Vortioxetine?



This medication has not been evaluated for use in pediatric patients.

Caution to be taken during initial stage of therapy or at the time of dosage change because there may be clinical worsening, suicidal ideation and unusual changes in behavior.

It may cause potentially life-threatening serotonin syndrome when used alone but more often when used concomitantly with other serotonergic drugs.

It may cause abnormal bleeding, activation of mania/hypomania and hyponatremia.

What are the side effects of Vortioxetine?

The most common side effects reported with vortioxetine are nausea, vomiting, diarrhea, headache, dizziness and sexual dysfunction.

What are the other precautions for Vortioxetine?


Avoid excess dosage.

What are the storage conditions for Vortioxetine?

Store at 77F (25C); excursions permitted to 59F to 86F (15C to 30C).



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