This medication is an antidepressant used for the treatment of major depressive disorder (MDD) in adults and also investigated as a treatment for generalized anxiety disorder (GAD).
Hypersensitivity to vortioxetine or any components of the formulation. Angioedema has been reported in patients treated with brintellix.
The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated, because higher doses demonstrated better treatment effects in trials conducted in the United States.
This medication is available as immediate-release, film-coated tablets to take by mouth, with or without food. It is available in 5 mg, 10 mg and 20 mg tablets.
• This medication has not been evaluated for use in pediatric patients.
• Caution to be taken during initial stage of therapy or at the time of dosage change because there may be clinical worsening, suicidal ideation and unusual changes in behavior.
• It may cause potentially life-threatening serotonin syndrome when used alone but more often when used concomitantly with other serotonergic drugs.
• It may cause abnormal bleeding, activation of mania/hypomania and hyponatremia.
The most common side effects reported with vortioxetine are nausea, vomiting, diarrhea, headache, dizziness and sexual dysfunction.
Avoid excess dosage.
Store at 77°F (25°C); excursions permitted to 59°F to 86°F (15°C to 30°C).
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