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Vedolizumab - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Vedolizumab

Generic Name : Vedolizumab
Pronunciation : ve-doe-liz-yoo-mab
Latest prescription information about Vedolizumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Vedolizumab


Overview of Vedolizumab

Vedolizumab is a monoclonal antibody used for treating moderate to severe active ulcerative colitis (UC) and Crohn’s disease (CD) in adults.

Why is Vedolizumab Prescribed? (Indications)

Vedolizumab injection is used for treating adult patients with moderate to severe active ulcerative colitis and Crohn’s disease who have had an inadequate response or no response or who were intolerant to other treatment methods such as with drugs that causes tumor necrosis factor (TNF) block (such as Infliximab or Etanercept) or an immunomodulatory (azathioprine, methotrexate or cyclosporine) or a corticosteroid.
It helps for inducing and maintaining clinical response and clinical remission, improving the endoscopic appearance of the mucosa and achieving corticosteroid-free remission.  

When should Vedolizumab not be taken? (Contraindications)

Vedolizumab should not be used:

• If there is an allergy to vedolizumab
• In patients with severe infections.

What is the dosage of Vedolizumab?

Vedolizumab is available as injection containing 300mg of drug
For adult UC and CD, it is given as 300 mg intravenous infusion over 30 minutes at zero, two and six weeks, thereafter for every eight weeks.

How should Vedolizumab be taken?

• Vedolizumab should be discontinued in patients who do not show therapeutic benefit by Week 14.
• It should be reconstituted and diluted with sterile water for injection prior to the administration. It should be reconstituted and prepared by a trained healthcare professional using aseptic technique.
• Injection should be given within four hours of reconstitution and dilution.
• Visually inspect the reconstituted vedolizumab injection for any particulate matter and discoloration prior to administration. Injection should be clear or opalescent, colorless to light brownish yellow and free of visible particulates.
• Discard any remaining portion of the injection.
• Do not add other medicines to the prepared infusion solution or intravenous infusion set. Injection should be used as soon as possible after reconstitution and dilution.

What are the warnings and precautions for Vedolizumab?

• Discontinue in case of an allergic reaction during infusion.
• Caution is needed in case of using vedolizumab in patients with progressive multifocal leukoencephalopathy (PML).
• Caution is needed in case of using vedolizumab in patients with liver damage.
• Caution is exercised in case of using vedolizumab in patients who are going to take live vaccines. Hence, patients are advised to bring their immunization card up to date.

What are the side effects of Vedolizumab?

Gastrointestinal: Nausea
Nervous system: Headache
Respiratory: Inflammation of Nose and pharynx (Nasopharyngitis), upper respiratory tract infection, fatigue, cough, bronchitis, influenza, sinusitis, oropharyngeal pain
Skin: Pruritus(itching)
Others: Back pain , pain in limbs(legs)

What are the other precautions for Vedolizumab?

Vedolizumab should be used during pregnancy only if the benefits to the mother are more than the risk to the unborn child.
Caution is needed when administering vedolizumab to breastfeeding women.

What are the Drug Interactions of Vedolizumab?

Vedolizumab may interact with natalizumab, live vaccines, and other immunomodulators

What are the storage conditions for Vedolizumab?

Refrigerate vedolizumab vials at 2° to 8°C (36º to 46ºF).
Last Updated : 11/20/2018

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