Trametinib belongs to a group of medicines called kinase inhibitors. It is prescribed for the treatment of a certain type of advanced stage skin cancer (melanoma) which has spread to other parts of the body or which cannot be treated by surgery. Trametinib is often given in combination with dabrafenib for patients with BRAF V600E or V600K mutations. It prevents the growth of cancer cells by blocking the MEK proteins which signals them to multiply.
Trametinib is contraindicated in patients who are allergic to the drug. It should be avoided or used with caution with the use of any medicine that may interfere with its effect or may increase its side effects, patients with history of heart problems, vision problems, liver, lung or kidney diseases, or diabetes. It should not be used during pregnancy and breast feeding.
The recommended dose of trametinib is 2 mg to be taken once daily on an empty stomach either one hour before meals or two hours after meals. It is also taken in combination with 150mg dabrafenib twice daily.
Trametinib comes in the form of a tablet to be taken by mouth on an empty stomach.
• Do not use the drug if you are planning to become pregnant as trametinib may cause harm to the fetus.
• Monitor blood glucose levels while taking trametanib as the drug is capable of causing high blood sugar level.
• Blood pressure should be checked from time to time as tramatenib can cause hypertension.
• Trametanib may cause fertility problems. It should be avoided by women of child bearing age.
• General: Swelling of the face, arms, legs and feet, fever, weakness, diarrhea, pain in abdomen.
• Skin: Rashes, severe skin reactions, skin infections, nail disease, itching. Skin toxicity may be serious enough to require hospitalization.
• Cardiovascular system: High blood pressure, cardiomyopathy (heart muscle related diseases), heart failure.
• Central nervous system: Dizziness
• Respiratory: Shortness of breath, difficulty in breathing, lung diseases, pneumonitis, cough, nose bleed.
• Blood: Anemia, low white blood cell count, bleeding.
• Eye: Blurred vision, dry eyes, loss of vision, retinal vein occlusion (blockage of blood supply to the retinal vein).
• Liver: Increase in liver enzymes.
Do not breast feed your baby while taking trametanib.
Trametinib should be taken on an empty stomach as intake of food may delay the absorption of the drug and reduce its effectiveness.
Trametinib should be avoided with:
CYP3A4 and CYP2C8 inducers or inhibitors when it is used along with dabrafenib.
Store the medicine in a tightly closed container. Keep it in a refrigerator, do not freeze. Protect it from light. Keep out of reach of children.