Name: Regorafenib
Creator: Dhanalakshmi Chinnuswamy
Published: 10/5/2012

Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)
Further Checked by The Medindia Medical Review Team on Oct 05, 2012

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Information about Regorafenib

Generic Name : Regorafenib

Latest prescription information about Regorafenib. Learn its indications, dosage, how to take, when to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Regorafenib

International- Stivarga.

Why is Regorafenib Prescribed? (Indications)

This medication is a kinase inhibitor, prescribed for metastatic colorectal cancer (CRC) in patients who have been previously treated with fluoropyrimidine- oxaliplatin-and irinotecan-based chemotherapy. It works by helping to stop cancer cells from growing.

What is the dosage of Regorafenib?

PO- The recommended dose is 160mg, once daily for the first 21 days of each 28-day cycle.

How should Regorafenib be taken?

It comes as a tablet to take by mouth with food.

What are the warnings and precautions for Regorafenib?

• Caution should be exercised in patients with history of bleeding problems, high blood pressure, heart, liver, or kidney diseases, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Avoid drinking grapefruit juice while taking this medication.

• Patient may develop with increased risk of Reversible Posterior Leukoencephalopathy Syndrome (RPLS). If it is so consult with your doctor immediately.

What are the side effects of Regorafenib?

•  Most Common: Weakness, fatigue, decreased appetite and food intake, Hand-foot skin reaction (HFSR) (palmar-plantar erythrodysesthesia [PPE]), diarrhea, weight loss, and infection.
•   General : Fever.
•   Metabolic : Anemia, weight loss.
•   Skin : Rash.
•   Gastrointestinal : Diarrhea.
•   Heart : High blood pressure, bleeding.
•   Respiratory : Difficulty in breathing.

What are the other precautions for Regorafenib?

Avoid excess dosage.

What are the storage conditions for Regorafenib?

Store it at controlled room temperature (15 to 30°C).

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Comments

arvindjava, India

Dear All, Can anyone help me with the supply of Regorafenib,my father is a CRC patient

B.K.DEY, India

Regorafenib [Stivarga] Drug Information is required. As this drug is not available in India. Can you let me Know which company is manufacturing or,Marketing this Drug in India. How to procure this drug for my friend on Prescription. My friend Dr Bharetendu Madeka , He is M.B.B.S Doctor himself suffering from Metastatic Colo rectal Cancer. Staying in Kolkata How can he get the medicine at a concessional rate and make the Drug easily available in Kolkata. Please Reply DR BIJAN KUMAR DEY. Email : deybijankumar@Yahoo.co.in

prem_gunjal, India

Dear Sir/Madam, I am in reqiurement of the regerofeneb tablets in pune. can anyone help me in this concern.

shomallajan, India

is regerofeneb available in india...if not how could I purchase it in india....

niftytrader, India

regerofenib available asia. niftytrader@gmail.com