This medication is a kinase inhibitor, prescribed for metastatic colorectal cancer (CRC) in patients who have been previously treated with fluoropyrimidine- oxaliplatin-and irinotecan-based chemotherapy. It works by helping to stop cancer cells from growing.

PO- The recommended dose is 160mg, once daily for the first 21 days of each 28-day cycle.

It comes as a tablet to take by mouth with food.

• Caution should be exercised in patients with history of bleeding problems, high blood pressure, heart, liver, or kidney diseases, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Avoid drinking grapefruit juice while taking this medication.

• Patient may develop with increased risk of Reversible Posterior Leukoencephalopathy Syndrome (RPLS). If it is so consult with your doctor immediately.

•  Most Common: Weakness, fatigue, decreased appetite and food intake, Hand-foot skin reaction (HFSR) (palmar-plantar erythrodysesthesia [PPE]), diarrhea, weight loss, and infection.
•   General : Fever.
•   Metabolic : Anemia, weight loss.
•   Skin : Rash.
•   Gastrointestinal : Diarrhea.
•   Heart : High blood pressure, bleeding.
•   Respiratory : Difficulty in breathing.

Avoid excess dosage.

Store it at controlled room temperature (15 to 30°C).