This medication is a kinase inhibitor, prescribed for metastatic colorectal cancer (CRC) in patients who have been previously treated with fluoropyrimidine- oxaliplatin-and irinotecan-based chemotherapy. It works by helping to stop cancer cells from growing.
PO- The recommended dose is 160mg, once daily for the first 21 days of each 28-day cycle.
It comes as a tablet to take by mouth with food.
• Caution should be exercised in patients with history of bleeding problems, high blood pressure, heart, liver, or kidney diseases, any allergy, who are taking other medications, during pregnancy and breastfeeding.
• Avoid drinking grapefruit juice while taking this medication.
• Patient may develop with increased risk of Reversible Posterior Leukoencephalopathy Syndrome (RPLS). If it is so consult with your doctor immediately.
• Most Common:
Weakness, fatigue, decreased appetite and food intake, Hand-foot skin reaction (HFSR) (palmar-plantar erythrodysesthesia [PPE]), diarrhea, weight loss, and infection.
• General : Fever.
• Metabolic : Anemia, weight loss.
• Skin : Rash.
• Gastrointestinal : Diarrhea.
• Heart : High blood pressure, bleeding.
• Respiratory : Difficulty in breathing.
Avoid excess dosage.
Store it at controlled room temperature (15 to 30°C).
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