Madhumathi Palaniappan
Written & Compiled by Madhumathi Palaniappan, B.Pharm
Medically Reviewed by The Medindia Medical Review Team on Apr 20, 2016
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General Information on Pregabalin

Generic Name : Pregabalin

Pronunciation : pre gab' a lin

Latest prescription information about Pregabalin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.6 | Therapeutic Classification : Anticonvulsants

Why is Pregabalin Prescribed? (Indications)

Pregabalin is an anticonvulsant used as an additional treatment of partial seizures. It is also effective against nerve-related pain as it decreases the number of pain signals sent out by the damaged nerves in the body. It is used in the management of postherpetic neuralgia (nerve pain caused by the chicken pox virus), painful peripheral neuropathy due to diabetes, nerve-related pain due to spinal cord injury and fibromyalgia (a condition where the patient has muscle and connective tissue pain). It is also used in the treatment of generalized anxiety disorder.  

When should Pregabalin not to be taken? (Contraindications)

Pregabalin should not be used in patients allergic to the drug.

What is the dosage of Pregabalin?

Dosage usually varies from 150 to 600 mg/day given orally in divided doses.

How should Pregabalin be taken?

Pregabalin comes as a capsule to take by mouth. It is usually taken with or without food two or three times a day.

What are the warnings and precautions for Pregabalin?

Dosage should be reduced in patients with kidney disease

Use with caution in patients with heart failure since it can cause peripheral edema and weight gain.

It may cause dizziness, drowsiness or blurred vision, do not drive a car or handle machinery after taking the medicine.

Caution should be advised to patients with decreased platelet counts and bleeding disorders, irregular heart rhythms, during pregnancy and breast feeding.

What are the side effects of Pregabalin?

  Central Nervous System: Dizziness, sleepiness, fatigue, euphoric mood, confusion, suicidal thoughts, irritability, abnormal movements, and problems with speech, memory or attention.
   Eye and ENT: Blurred vision, double vision, vertigo
  Gastrointestinal: Dry mouth, constipation, increased appetite, flatulence, vomiting, abdominal distension, abdominal pain, diarrhea, nausea.
   Genitourinary: Urinary incontinence, sexual dysfunction
  Cardiovascular Heart failure, problems with heart rhythm
  Musculoskeletal: Pain in muscles and joints.
  Respiratory:Inflammation of nose and upper throat, difficulty with breathing
  Blood - Reduced platelet count which may result in easy bruising
   Miscellaneous: Allergic reaction called angioedema which results in face and throat swelling and difficulty with breathing, fluid retention, swelling of feet, weight gain, low blood sugar

What are the other precautions for Pregabalin?

Avoid alcohol consumption while taking this medication.
Do not discontinue the medicine suddenly without consulting the doctor as it may lead to withdrawal symptoms.

What are the Drug Interactions of Pregabalin?

Some of the drugs that should be avoided or used with caution with pregabalin include the following:
ACE inhibitors like captopril, enalapril , lisinopril, fosinopril, perindopril, ramipril as it results in swelling of the face, neck and mouth leading to breathing difficulty.
Benzodiazepines like clobazam and lorazepam, barbiturates like phentobarbital and butobarbital, other sedative medications and alcohol due to additive sedative effect.
Certain antidiabetic drugs like rosiglitazone and pioglitazone as they enhance fluid retention.
Orlistat used in the treatment of obesity as it inhibits absorption of pregabalin from the digestive tract.

What are the storage conditions for Pregabalin?

Store it in a closed container at room temperature. Protect from heat, moisture and light. Keep out of reach of children.

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manas27, India

My wife is suffering from a chest pain almost one month.She has low presser [70-110] most of the time. And doctor said its not a heart related pain, prescribed pregabalin methylcobalamin capsules vit- d calcium and indomethacin tab. But after taking pregabalin most probably she is feeling nausea and problem to walk. Her RA/uric acid/ECG is normal. Plz advice me me what should I do?

madmax1950, United States

I need pricing for Lyrica in USD rather than rupees. How can we accomplish this??? Thank You

Drmohammedaijaz, United States

This drugs have these many side effect so wt s d need to take for a single and simple disease

Buy Medicines (Drug) at Concessional Price from India

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