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General Information on Levetiracetam

Generic Name : Levetiracetam

Pronunciation : LEE-va-tye-RA-se-tam

Latest prescription information about Levetiracetam. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.6 | Therapeutic Classification : Anticonvulsants

Why is Levetiracetam Prescribed? (Indications)

This medication is an anticonvulsant, prescribed for partial seizures. It works by reducing the activity in the brain. It can be used alone or with other antiepileptic medications. 

When should Levetiracetam not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Levetiracetam?

PO/IV- Adjunct in partial seizures- Initial: 500 mg twice daily on the 1st day, may increase gradually. Max: 3 g/day.
Monotherapy for partial seizures with or without secondary generalization- Initial: 500 mg/day, may increase gradually. Max: 3 g/day.

How should Levetiracetam be taken?

May be taken with or without food. (Oral solution should be diluted in a glass of water.) Administer IV levetiracetam as 15-min infusion following dilution in 100 ml of a compatible diluent.

What are the warnings and precautions for Levetiracetam?

Caution should be exercised in patients with history of liver or kidney problems, allergic reactions, patients undergoing haemodialysis, pregnancy and breastfeeding.

Patient may develop mood changes, suicidal thoughts.

It may impair ability to drive or operate machinery during initial therapy.

What are the side effects of Levetiracetam?

  Central Nervous System: Drowsiness, weakness, headache, hostility, fatigue, nervousness, dizziness, personality disorder, irritability, agitation, emotional lability, depression, mood swings, vertigo, anxiety, unsteadiness, seizures, memory loss, confusion, increased reflexes, tingling, aggression and suicidal behavior.
  Skin: Itching, skin discoloration, rash and loss of hair.
  Eye and ENT: Inflammation of nasopharynx, stuffy nose, inflammation of conjunctiva, blurred vision, double vision and ear pain.
  Gastrointestinal: Vomiting, loss of appetite, diarrhea, nausea, gastroenteritis, constipation and inflammation of pancreas.
  Genitourinary: Albumin in urine and urine abnormality.
  Blood: Easy bruising, deficiency of all three blood cell types (with bone marrow suppression in some cases).
  Liver: Abnormal LFTs (liver function test), liver failure and inflammation.
  Metabolic: Dehydration and weight loss.
  Musculoskeletal: Neck pain.
  Respiratory: Increased cough, asthma and sinusitis.
  Miscellaneous:Accidental injury, infection, influenza, pain, flu syndrome, face edema and viral infection.

What are the other precautions for Levetiracetam?

Do not change the dosage.

What are the storage conditions for Levetiracetam?

Intravenous: Once reconstituted store at 15-30C and use within 24 hr. Store tablets, oral solution, and undiluted IV injection at 15-30C.

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rajib777, India

Am on Levipil 500 along with Eptoin 100 and earlier had a brain surgery post diagnosis of AVM but the problem i am facing almost all the side effects which are mentioned above so in this case could u please suggest what should i do ?

kapadi111, India

I am a bipolar patient.Initially I started with LiCO3, Now I am under Sodium valporate and keeping reasonably OK for last15 yrs or so. Now i have been prescribed Torlev500. Why and what are the merits in terms of managing the disorder and reducing side effects. I am above 60 and female

AshokTanwar, India

Hi, I am Shruti, taking Tegrital 200 twice daily from last three years. No Seizure seen after first initial seizure when medicine started. Now, doctor added Levipil 500 twice daily alongwith Tegrital 200. When should I get the EEG repeated for checking improvements and what are the side effects.

NIRANJAN_PAN.DOC, India

I am niran jan pan Lived in Garhbeta, paschim Medinipur, West bengal last 14 years.After 2 years doctor catch my deases and then started proper medicine .After 6 month or 2 yerars left i am suffuring some problem just like some mentaly disorder but after that again iam well. Now iam treat under Doctor "Maloti Ghosh" She lived in Calcutta.She given the medicine namely are- Dicorate Er 1gm daily at night (once),Quitipin SR 100mg & livipil XR 500 at a night (once)

Brookenuts, United States

I take 2000mg daily now and have increased asthma every time the dosage was increased, it is to the point now that I can only go about 4 hours without an inhaler or a breathing treatment but my doctors insits that its not the Keppra and are sending me to a pulmonary specialist. I had a brain tumor removed and then a gand mahl and still have small breakthrough seizures but only when I try to excercise or over exert myself. I just cant breathe and feel like Im going to die!

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