Flucytosine - Indications, Dosage, Side Effects and Precautions


Information about Flucytosine

Generic Name : Flucytosine
Up-to-date prescription details regarding Flucytosine are provided here.

Pronunciation : floo-SYE-toe-seen

Learn the correct pronunciation of the Flucytosine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y40.7 Therapeutic Classification : Antifungals

Trade Names/Brand Names of Flucytosine

International :


Why is Flucytosine Prescribed? (Indications)

This medication is an antifungal agent, prescribed for serious infections (eg- candida, meningitis and pulmonary infections) caused by certain fungi either alone or with other medications. It works by slowing the growth of fungi that cause infection.

When should Flucytosine not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity to the drug.

What is the dosage of Flucytosine?

Adult- PO- The usual dosage is 50 to 150 mg/kg/day administered in divided doses at 6-hour intervals.

How should Flucytosine be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Flucytosine?

• Caution should be exercised in patients with history of bone marrow or blood problems, kidney impairment, who are taking other medications, any allergy, during pregnancy and breastfeeding.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• It may reduce platelet counts; avoid injury or bruising.

• Monitor complete blood cell counts, kidney and liver function tests, and blood electrolyte levels regularly while taking this medication.Avoid exposure to sunlight.

What are the side effects of Flucytosine?

Heart - Heart arrest, myocardial toxicity and ventricular dysfunction.
Respiratory - Respiratory arrest, chest pain and difficulty in breathing.
Skin - Rash, itching, hives and sensitivity to light.
Gastrointestinal - Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, dry mouth, duodenal ulcer, gastrointestinal bleeding, acute liver injury, liver dysfunction, jaundice, ulcerative colitis, increased level of liver enzymes.
Genitourinary - Creatinine and BUN elevation, crystal in urine and kidney failure.
Blood - Anemia, eosinophilia, decrease in white blood cells and platelets.
Central Nervous System - Incoordination, hearing loss, headache, tingling, Parkinsonism, peripheral neuropathy, fever, fainting, sleepiness, epilepsy, confusion, hallucinations and psychosis.
Miscellaneous - Fatigue, decrease in blood potassium and sugar level, weakness, allergic reactions, Lyell's syndrome.

What are the other precautions for Flucytosine?

Avoid excess dosage.

What are the storage conditions for Flucytosine?

Store it at room temperature (25°C).