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Last Updated : 6/1/2018

General Information on Erenumab-aooe

Generic Name : Erenumab-aooe

Pronunciation : e-REN-ue-mab-aooe

Latest prescription information about Erenumab-aooe. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Erenumab-aooe

Aimovig

Overview of Erenumab-aooe

Erenumab-aooe is a human monoclonal antibody approved by FDA in May 2018 to use as a subcutaneous injection for the preventive treatment of migraine in adults.

Why is Erenumab-aooe Prescribed? (Indications)

Erenumab-aooe injection is prescribed to prevent migraine headaches in adult patients.

Erenumab-aooe is a human immunoglobulin G2 monoclonal antibody that works by specifically blocking the calcitonin gene-related peptide receptor (CGRP) which is responsible for causing a migraine. 

When should Erenumab-aooe not to be taken? (Contraindications)

Erenumab-aooe should not be used in patients with-

Allergy to erenumab-aooe
Children under 18 years of age

Caution is required in treating-

Pregnant and breastfeeding women
Elderly patients

What is the dosage of Erenumab-aooe?

The recommended adult dose is 70 mg taken once a month.

In some specific cases, patients may be prescribed 140 mg which can be taken in two divided doses of 70 mg in a month.

If a dose is missed, it should be taken as early as possible and the next schedule will be after a month from the date of the last dose.

How should Erenumab-aooe be taken?

Erenumab-aooe injection comes as a single-dose prefilled syringe or prefilled autoinjector and should be administered subcutaneously or just under the skin.

Erenumab-aooe injection should be administered into the thigh, upper arm or abdomen.

The injection should be removed from the refrigerator and allowed to come to room temperature by keeping it out of the cold storage for at least 30 minutes.

Do not bring the injection to room temperature by keeping it in sunlight or by using some other source of heat such as a microwave oven or hot water.

Never shake the prefilled syringe or the autoinjector containing the injection as it may result in foaming.

What are the warnings and precautions for Erenumab-aooe?

Before injecting, check the contents of the injection to ensure whether it is clear and free from particulate matter. If discoloration or any particulate matter is seen, discard the injection immediately.

Patients should be advised to use new injection sites each time for injecting erenumab-aooe as it is always recommended to rotate the sites.

The autoinjector and the prefilled syringe contain caps made of dry rubber which may cause some allergic reactions in patients who are allergic to dry rubber or latex.

Patients must be trained accordingly by a healthcare provider about the handling and usage of erenumab-aooe injection before self-injecting at home.

Never inject into scars, moles, and areas where there is tender, red, bruised, hard or scaly skin.

Patients are advised to consult the physician immediately if any unwanted side effects or life-threatening conditions occur.

What are the side effects of Erenumab-aooe?

The most common side effects of erenumab-aooe include-

Constipation
Muscle pain
Injection site reactions such as pain, swelling or redness

What are the other precautions for Erenumab-aooe?

Do not recommend to other people who suffer from a migraine or never take this injection for the reason it is not prescribed.

Erenumab-aooe injection is intended for single use only.

What are the Drug Interactions of Erenumab-aooe?

Not known.

However, patients must inform the prescriber about the intake of any prescription drugs, over-the-counter medicines or herbal supplements to avoid unexpected effects with erenumab-aooe.

What are the storage conditions for Erenumab-aooe?

Store erenumab-aooe injection in a refrigerator at 2C to 8C.

Protect erenumab-aooe injection from light by placing it in its original package.

Do not freeze or shake.

Erenumab-aooe injection can be stored at room temperature between 20C and 25C for a week after removing from the refrigerator but should be discarded after a week if not used thereafter.

Last Updated : 6/1/2018
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