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Last Updated : 12/30/2016

General Information on Eluxadoline

Generic Name : Eluxadoline

Latest prescription information about Eluxadoline. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Eluxadoline


Why is Eluxadoline Prescribed? (Indications)

Eluxadoline is a drug that is prescribed for the treatment of irritable bowel syndrome with diarrhea. Irritable bowel syndrome is a condition which causes abdominal cramps, stomach pain, bloating, and either diarrhea or constipation in the absence of any specific abnormality of the digestive tract. The drug decreases bowel movements by acting on certain molecules in the digestive tract called mu-opioid receptors. 

When should Eluxadoline not to be taken? (Contraindications)

Eluxadoline should not be prescribed to patients who are allergic to the drug, patients with pancreatic or severe liver disease or bile duct obstruction, with the use of certain other medications or alcohol, in patients who suffer from severe constipation, or during pregnancy and breast feeding.

What is the dosage of Eluxadoline?

The recommended dose of the drug is 100mg to be taken twice daily along with food.

In case of patients with mild-to-moderate liver disease, patients who do not have a gall bladder and who are unable to tolerate 100mg of the drug, the dose of the drug is reduced to 75mg twice daily. This dose is also used in patients taking drugs like cyclosporin, gemfibrozil, anti-HIV drugs like lopinavir, saquinavir and tipranavir, and rifampin, which can increase the blood level of eluxadoline.

How should Eluxadoline be taken?

Eluxadoline comes in the form of a tablet to be taken twice daily along with food.

What are the warnings and precautions for Eluxadoline?

Do not consume alcoholic beverages while taking eluxadoline as it may increase the risk of pancreatitis (inflammation of the pancreas).

Like other opioids, eluxadoline can cause spasm of the sphincter that controls the flow of bile and pancreatic juice into the small intestine, called the Sphincter of Oddi. Patients without a gall bladder should be monitored regularly while taking eluxadoline as it can worsen abdominal pain and increase the levels of liver and pancreatic enzymes following the spasm.

There is a possibility of dependence to eluxadoline if taken for a prolonged duration.

Do not drive vehicle or operate heavy machinery while taking eluxadoline as it can cause dizziness and drowsiness.

Consult your doctor if you are planning pregnancy or breast-feeding the child during eluxadoline treatment.

What are the side effects of Eluxadoline?

  Gastro-intestinal System: Nausea, vomiting, abdominal cramps, constipation, flatulence, pancreatitis
  Respiratory System - Upper respiratory tract infection, bronchitis
  Skin - Rash

What are the other precautions for Eluxadoline?

Inform the doctor if you have a history of pancreatitis or severe constipation before taking the drug.

What are the Drug Interactions of Eluxadoline?

Eluxadoline should be avoided with:

OATP1B1 Inhibitors - Drugs like cyclosporin, gemfibrozil, anti-HIV drugs like lopinavir, saquinavir and tipranavir, and rifampin may increase the blood levels of eluxadoline.

CYP Inhibitors - Ciprofloxacin, fluconazole, clarithromycin, fentanyl, pimozide, quinidine, paroxetine and bupropion may increase the blood level of eluxadoline.

Drugs that induce constipation - Anticholinergic drugs, opioid drugs like loperamide, and alosetron which cause constipation should not be taken with eluxadoline as the combination can cause severe constipation.

Rosuvastatin Eluxadoline increases the blood levels of rosuvastatin thereby increasing the risk of its serious side effect, rhabdomyolysis (breakdown of skeletal muscle) and myopathy (muscular disease.

What are the storage conditions for Eluxadoline?

Store the medicine in a tightly closed container at room temperature. Protect from excess heat, light and moisture. Keep out of reach of children.

Last Updated : 12/30/2016

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