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Dydrogesterone - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Dydrogesterone

Generic Name : Dydrogesterone
Pronunciation : dy·dro·ges·ter·one
Latest prescription information about Dydrogesterone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
ICD Code : (Y42.5-Y42.6) | Therapeutic Classification : Progestins
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Trade Names/Brand Names of Dydrogesterone

Climaston, Dabroston, Dufaston, Duphaston, Terolut

India : 

Following are the Dydrogesterone Combinations:

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Overview of Dydrogesterone

Dydrogesterone is a synthetic progesterone. Progesterone is a female hormone which is responsible for the healthy growth of the womb (uterine) lining also known as endometrial. If the egg released during the menstrual cycle is not fertilized, progesterone levels decrease and initiates proper shedding of the womb lining (menstruation). If the egg is fertilized and attaches to the womb lining, progesterone levels continue to increase and helps in maintaining the integrity of womb lining which is very necessary to preserve the pregnancy.
Dydrogesterone is used to mimic the action of progesterone in various conditions

Why is Dydrogesterone Prescribed? (Indications)

  • Menstrual disorders: Since the drug supports normal growth and shedding of the uterine lining, it is used for treating menstrual disorders like absent or irregular menstruation, painful menstruation, secondary amenorrhea and premenstrual symptoms.
  • Prevent miscarriage: Since the drug helps in maintaining integrity of the endometrial lining in a pregnant womb, it is used for preventing habitual and recurrent abortion.
  • Endometriosis: Dydrogesterone relieves the pain during menstruation due to endometriosis without inhibiting ovulation.
  • Infertility: The drug is used during IVF (in-vitro fertilization) cycle to achieve successful implantation.
  • In combination with hormonal replacement therapy (HRT): Dydrogesterone prevents thickening of the uterine lining in the patient taking HRT.
 
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When should Dydrogesterone not be taken? (Contraindications)

Contraindicated in patients with undiagnosed, abnormal vaginal bleeding, blood clot disorder, stroke, incomplete abortion, breast cancer, brain cancer, breastfeeding mothers, liver dysfunction, and hypersensitivity.
The drug is contraindicated in children under age 18 years.
While the drug is useful in sustaining pregnancy in patients with recurrent abortion, the drug is contraindicated in pregnant patients who are not at any risk of abortion or in patients with advanced pregnancy.

What is the dosage of Dydrogesterone?

Drug dosage varies as per the medical condition.
  • Painful menstruation and irregular menstrual periods: 10 mg twice daily from starting from the 5th day of the menstrual cycle to the 25th day.
  • Endometriosis: 10 mg twice or thrice daily starting from the 5th day of the menstrual cycle to the 25th day.
  • Dysfunctional bleeding/ unexpected bleeding:
  • 10 mg twice daily for a week for stopping bleeding.
  • 10 mg twice daily starting from the 11th day of the menstrual cycle to 25th day to prevent heavy bleeding.
  • Secondary Amenorrhea: Should be given in combination with estrogen therapy. 10 mg twice daily starting from the 11th day of the menstrual cycle to the 25th day.
  • Abortion: In case of threatened abortion, 40 mg immediately and then 10 mg doses repeated every 8 hours till remission.
  • In case of habitual abortion, 10 mg once daily till 12th week of pregnancy.
  • Infertility: 10 mg once daily from 14th day of menstrual cycle to 25th day.
  • In post-menopausal conditions: Should be given in combination with estrogen therapy in a dose of 2.5 mg to 10 mg once daily as per the severity of the condition.

How should Dydrogesterone be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Dydrogesterone?

• Patients should be monitored for visual disturbances, migraine headache or embolic disorders.
• The duration and the frequency of the treatment should be decided by the treating physician.
• If any allergic reaction reactions occur, the medicine has to be stopped and should consult a physician.

What are the side effects of Dydrogesterone?

  • Pulsating headache which can develop into a migraine
  • Pain in breast and breast tenderness
  • Occasional blood spotting
  • Pain during periods
  • Irregular period
  • Heavy bleeding during periods
  • Missed period
  • Weight gain
  • Depression
  • Abnormal liver function which can progress into jaundice Nausea and abdominal discomfort
  • Hypersensitivity

What are the other precautions for Dydrogesterone?

Caution should be exercised in patients with a history of blood clot disorder, kidney impairment, heart disease, epilepsy, asthma, migraine, fluid retention, and breastfeeding. Monitor closely eye vision and symptoms of blood clot disorders.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Should be used with extreme care in patient with a history of clinical depression.

What are the Drug Interactions of Dydrogesterone?

No specific symptoms are observed with drug overdose. Treatment is symptomatic and supportive.

What are the storage conditions for Dydrogesterone?

Store in a dry, dark place at temperatures not exceeding 25°C. Keep out of reach of children.



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Comments

sana123456789, Sri Lanka

my wife age is 37 yrs . geting 20mg in night [10mg*2nos].Any harm. pse let me know

MarieEstillore, United Kingdom

Can it be taken by person with diabetes who has daily medication for anti diabetes and Vitamin B complex and Vitamin D3 ? And can it be taken by person with allergic reaction to Nubaine?

joline, N/A

i am age 46, and has stopped having mensus for about 1 year plus. last week my GP recommended me to take Femoston 1/10 table to get my period back as the doctor said that due to my early age of menopause it will cause oestoperasis. I did not experience any symtoms of menopause as i did regular exercise. I am concern about the side effect of taking this medicine. I am at good health but i afraid of oestoperasis. can i take the oestoperasis medicine instead of hormone therapy pills which cause side effects. pls advise thank you.

basma_saqr, Egypt

can it taken with aspirin ?

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