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Dapagliflozin - Indications, Dosage, Side Effects and Precautions

Last Updated on Dec 10, 2016
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Information about Dapagliflozin

Generic Name : Dapagliflozin
Latest prescription information about Dapagliflozin. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Endocrine and Metabolic Agents
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Trade Names/Brand Names of Dapagliflozin

FARXIGA
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Why is Dapagliflozin Prescribed? (Indications)

Dapagliflozin is a sodium - glucose cotransporter 2 inhibitor (SGLT2) which is prescribed to lower the blood sugar levels in patients with type 2 diabetes. Dapagliflozin is usually given along with diet and exercise.

The drug mainly acts by causing the kidneys to get rid of glucose in the urine.
 
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When should Dapagliflozin not be taken? (Contraindications)

Dapagliflozin is contraindicated in patients who are allergic to the drug, have type 1 diabetes or diabetic ketoacidosis (a life-threatening complication of diabetes with a high concentration of ketones in the body), patients with the history of severe kidney disease or kidney failure and bladder cancer (since a few cases of bladder cancer have been noted in patients taking dapagliflozin). It is ineffective in patients with moderate kidney disease and also caused side effects. It should not be prescribed during pregnancy and breastfeeding.

What is the dosage of Dapagliflozin?

The recommended dose of dapagliflozin is 5mg to be taken once daily in the morning with food or on an empty stomach. The dose can be increased to 10 mg daily if required.

How should Dapagliflozin be taken?

Dapagliflozin comes in the form of a tablet to be taken orally.

What are the warnings and precautions for Dapagliflozin?

Dapagliflozin may cause serious kidney problems, therefore monitor kidney functions while taking the drug.

Consult the doctor before having any surgery, even a dental surgery, while taking medicine.

Get up slowly from the lying position; dapagliflozin may cause low blood pressure resulting in dizziness, lightheadedness or fainting.

Dapagliflozin interacts with the urine glucose test. A urine glucose test is often carried out to measure the quantity of glucose present in the urine sample of diabetes patients. The urine may test positive for glucose if the patient is taking dapagliflozin even if glucose is absent. Therefore, alternative methods have to be followed to test sugar levels in patients taking dapagliflozin.

What are the side effects of Dapagliflozin?

  General: Weakness, feeling tired.
  Gastrointestinal: Nausea, vomiting, pain in the stomach.
  Urinary System: Frequent urination which may result in dehydration and low blood pressure; urinary and genital fungal infection or other urinary tract infections resulting in symptoms of burning sensation while urinating, vaginal discharge in women, cloudy urine or penis discharge in men; and reduced kidney function which can cause bone fractures.
  Allergic reactions: Rash, hives, itching of the skin, breathing difficulties, swelling of the face, lips, mouth or the tongue.
  Blood: Low blood sugar levels, increase in cholesterol levels.

What are the other precautions for Dapagliflozin?

Consuming alcohol may cause changes in the blood sugar level; consult with your physician on the safe use of alcohol while taking dapagliflozin.

Caution should be exercised in patients with low blood pressure during treatment with dapagliflozin. Low blood volume should be corrected before treatment with dapagliflozin.

It should be used with caution in patients at a risk for bone fracture.

What are the Drug Interactions of Dapagliflozin?

Consult your doctor before taking blood pressure and heart medications like enalapril, rampril, losartan, candesartan, irbesartan as dapagliflozin can lead to hypovolemia (condition where blood circulation is low).

Other antidiabetic medications such as glimepiride, glipizide and insulin can further lower down the blood glucose levels of the patient taking dapagliflozin, sometimes even resulting in hypoglycemia. Other drugs that can alter blood sugars level like quinolone antibiotics and salicylates should also be used with caution.

Diuretic medications with dapagliflozin might increase the risk of low blood pressure.

What are the storage conditions for Dapagliflozin?

Store dapagliflozin in a tightly closed container at room temperature. Protect from excess heat and moisture. Keep out of reach of children.
Last Updated : 12/10/2016



Dapagliflozin : Frequently Asked Questions

Q: Does dapagliflozin lowers blood pressure?

A: Dapagliflozin showed significant reduction in blood pressure . Dapagliflozin showed a significant reduction in blood pressure in both hypertensive and non-hypertensive patients with type 2 diabetes (1 Trusted Source
Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes

Go to source
).

Q: Does dapagliflozin damage kidneys?

A:  Dapagliflozin reduces the risk of kidney failure and prolongs survival in people with chronic kidney disease . It protects patients with CKD who are at risk of progression due to worsening kidney function and end-stage renal disease (2 Trusted Source
Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease

Go to source
).

Q: When is the best time to take dapagliflozin?

A: Dapagliflozin should be taken once daily in the morning with food or on an empty stomach (3 Trusted Source
Dapagliflozin

Go to source
).

Q: Does dapagliflozin affect the heart?

A: Dapagliflozin reduces the risk of heart failure and cardiovascular death . It also improves quality of life in patients with heart failure (4 Trusted Source
Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes

Go to source
).

Q: Does dapagliflozin cause hypoglycemia?

A:  Dapagliflozin alone does not cause hypoglycemia . It may cause hypoglycemia when combined with other oral hypoglycemic agents (5 Trusted Source
The efficacy and safety of dapagliflozin combined with oral hypoglycemic agents in patients with type 2 diabetes: a systematic review and meta-analysis

Go to source
).

  • 1. Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes - (https://www.researchgate.net/publication/277252010_Dapagliflozin_lowers_blood_pressure_in_hypertensive_and_non-hypertensive_patients_with_type_2_diabetes)
  • 2. Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease - (https://pubmed.ncbi.nlm.nih.gov/33186054/#)
  • 3. Dapagliflozin - (https://medlineplus.gov/druginfo/meds/a614015.html)
  • 4. Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157181/#:)
  • 5. The efficacy and safety of dapagliflozin combined with oral hypoglycemic agents in patients with type 2 diabetes: a systematic review and meta-analysis - (https://pubmed.ncbi.nlm.nih.gov/35365032/#:)
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