Clomiphene Medication Information
Learn everything you need to know about Clomiphene-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it.
Get up-to-date information on side effects, precautions, warnings, and proper storage to ensure safe usage.
Explore Clomiphene brand names commonly used in India and internationally, along with detailed pricing information. Consult your healthcare provider for tailored medical advice.
Generic Name : Clomiphene Pronunciation : KLOE-mih-feen Therapeutic Classification : Fertility DrugBrand Names or Trade Names of Clomiphene
India :
Clophene |
Clome (100 mg) |
Fetrop (50mg) |
Clomidac (50mg) |
Ovofar |
Ovofar |
Fertex (100mg) |
Clomiriv - 25 |
Fertomid (100mg) |
Siphene M
International :
Clomid, Serophene
Why is Clomiphene Prescribed? (Indications)
Clomiphene medication is an ovulatory stimulant, prescribed for infertility due to anovulation or when there is no ovulation. It increases production of gonadotropins and causes the ovaries to release one or more eggs.Clomiphene is most commonly used to treat male infertility too by overcoming the hormonal imbalances that can affect sperm production.( 1✔ ?Trusted Source
Effect of clomiphene citrate on sperm density in male partners of infertile couples
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It works by the following mechanism:
Stimulates Hormone Production: Clomiphene is a selective estrogen receptor modulator (SERM). It blocks estrogen receptors in the brain, particularly in the hypothalamus and pituitary gland. This blocking action tricks the brain into thinking estrogen levels are low, prompting the hypothalamus to release more gonadotropin-releasing hormone (GnRH).
Increases Testosterone Levels: The GnRH release will also stimulate the pituitary gland to release a hormones called luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones play a critical role in testosterone production and spermatogenesis (sperm production) in the testes.
Improves Sperm Count and Quality: The increase in FSH directly supports the production and maturation of sperm, potentially improving sperm count, motility, and morphology.
Clomiphene will not be effective if the cause of male infertility is non-hormonal, such as anatomical issues or severe genetic abnormalities.
When should Clomiphene not be taken? (Contraindications)
Contraindicated in patients with liver or thyroid disease, brain tumor, pregnant or breast feeding women, or patients with allergy to the drug.What is the dosage of Clomiphene?
For Female ovulatory stimulation: Orally to be given in dosage of 50 mg/day for 5 days starting on the 5th day of menstrual cycle or at any time if there is absence of a menstrual period. It may be increased to 100 mg/day for the 2nd course as early as 30 days after previous therapy if needed. Total max: 6 treatment cycles.For Male Infertility: The dose is 25 mg to be taken once a day for 25 days followed by a break of 5 days and then to restart again. It can be tried for 3 to 6 months. Do remember that it takes 90-120 days from the time a sperm is made until it is ejaculated. Some infertility trials have administered clomipnhe for upto 3 years with good results( 2✔ ✔Trusted Source
Long-Term Safety and Efficacy of Clomiphene Citrate for the Treatment of Hypogonadism
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How should Clomiphene be taken?
It comes as a tablet to take by mouth. It is usually taken once a day.What are the warnings and precautions for Clomiphene?
•It may cause, uterine fibroids, blurred vision, dizziness. Do not drive a car or operate machinery, especially in poor lighting, until you know how this medication affects you.Polycystic ovaries, evaluate presence of ovarian cyst before each cycle treatment.
What are the side effects of Clomiphene?
Heart- Vasomotor flushes.Central Nervous System- Headache, dizziness, lightheadedness.
Eye- Visual symptoms, blurring spots or flashes, double vision, photophobia.
Gastrointestinal- Abdominal pain/discomfort, distension, bloating, nausea, vomiting.
♦ Genitourinary- Multiple pregnancies, abnormal ovarian enlargement, abnormal uterine bleeding; ovarian cyst formation, ovarian hyperstimulation syndrome , risk of ovarian tumor.
Liver- Liver function tests abnormalities.
♦ Miscellaneous- Breast tenderness and hives.
Long term of use of Clomiphene in men who use it for infertility, it was found that there were no major side effects recorded. The most common side effects reported by patients treated more than 3 years included changes in mood, blurred vision and breast tenderness There was no significant adverse event in any patient treated with clomiphene citrate.
