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General Information on Caplacizumab-yhdp

Generic Name : Caplacizumab-yhdp

Latest prescription information about Caplacizumab-yhdp. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Caplacizumab-yhdp

Cablivi

Overview of Caplacizumab-yhdp

Caplacizumab is a von Willebrand factor (vWF)-mediated antibody used for treating acquired thrombotic thrombocytopenic purpura (aTTP).
vWF is a factor required for blood clotting.
aTTP is a blood disorder with low platelet count, areas of bleeding under the skin (purpura), low red blood cell count, and anemia.

Why is Caplacizumab-yhdp Prescribed? (Indications)

Caplacizumab is prescribed for treating acquired thrombotic thrombocytopenic purpura (aTTP) 

When should Caplacizumab-yhdp not to be taken? (Contraindications)

Previous severe allergic reaction to caplacizumab-yhdp.

What is the dosage of Caplacizumab-yhdp?

Caplacizumab should be administered upon the initiation of plasma exchange therapy.

The first dose should be given by a healthcare provider as a bolus( at a time) intravenous injection.

The recommended dose is as follows:
1st day: 11 mg bolus intravenous( into the vein) injection 15 minutes before plasma exchange followed by 11 mg subcutaneous injection (into the fat layer of skin) after completion of plasma exchange on day 1.

Subcutaneous injection in the abdomen once daily for 30 days after plasma exchange.

Missed a Dose?

If a dose of Caplacizumab is missed during the plasma exchange, it should be given as soon as possible. If a dose is missed after the plasma exchange, it should be given within 12 hours of the scheduled time of administration. After 12 hours, the missed dose should be skipped and the next daily dose should be given according to the usual dosing schedule.

How should Caplacizumab-yhdp be taken?

Caplacizumab is given by injection -into the vein or into the fat layer of skin by a health care provider.

What are the warnings and precautions for Caplacizumab-yhdp?

Caplacizumab increases the risk of bleeding like epistaxis(nasal bleeding), gingival(gum) bleeding, gastrointestinal bleeding etc especially among patients with diseases like hemophilia and other clotting factor deficiencies.

Stop caplacizumab for 7 days before any planned surgery, dental procedures or other invasive interventions. If emergency surgery is required, the use of von Willebrand factor concentrate should be considered.

What are the side effects of Caplacizumab-yhdp?

Side effects include:
  Gastrointestinal : Gum bleeding, rectal hemorrhage, abdominal wall hematoma
  General: Fatigue (tiredness), fever, bleeding and itching at injection site, catheter site hemorrhage
  Musculoskeletal: Back pain, muscle pain
  Nervous system :Headache,
  Renal:-Urinary tract infection ,Blood in urine
  Reproductive system :Vaginal hemorrhage ,Menorrhagia(excess bleeding during mensus)
  Respiratory: Epistaxis ,Dyspnea(difficulty breathing)
  Skin: Urticaria (generalized skin reaction)

What are the other precautions for Caplacizumab-yhdp?

Caplacizumab may increase bleeding risk in the fetus and neonate. Pregnant women receiving caplacizumab should be carefully monitored for evidence of excessive bleeding.

What are the Drug Interactions of Caplacizumab-yhdp?

Usage of caplacizumab with other anticoagulants increase bleeding risks.

What are the storage conditions for Caplacizumab-yhdp?

Store caplacizumab in refrigerator 2C to 8C. Do not freeze and protect from light. Unopened vial of caplacizumab can be stored in the original carton at room temperature up to 2 months.

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