Information about BinimetinibGeneric Name : Binimetinib
Up-to-date prescription details regarding Binimetinib are provided here.
Pronunciation : bin-i-ME-ti-nib
Learn the correct pronunciation of the Binimetinib, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Chemotherapy
Trade Names/Brand Names of Binimetinib
Overview of BinimetinibBinimetinib tablets for oral use are prescribed in combination with encorafenib capsules for treating melanoma in adult patients. However, it should be used if the melanoma has a specific gene mutation.
Why is Binimetinib Prescribed? (Indications)Binimetinib tablets are prescribed in combination with encorafenib for treating adult patients with a specific type of skin cancer known as melanoma which either cannot be removed by surgery or has moved to other parts of the body.
Binimetinib should be used to treat melanoma with a BRAF V600E or V600K gene mutation as confirmed by an FDA approved test.
When should Binimetinib not be taken? (Contraindications)Binimetinib should not be used in patients-
• Allergic to binimetinib
• Pregnancy and breastfeeding
Binimetinib should not be used in children as safety and effectiveness of binimetinib has not been studied for their age groups.
Caution is required while treating patients with-
• Heart problems
• Liver disease
• Airway difficulties
• Eye disorders
• History of bleeding
What is the dosage of Binimetinib?• The recommended adult dose of binimetinib is 45 mg taken two times a day in combination with encorafenib capsules.
• The dose of binimetinib can either be reduced or modified based on the side effects that occur in patients treated with binimetinib.
• Treatment with binimetinib can permanently be discontinued or stopped if the side effects are severe or life-threatening.
• Do not continue the treatment with binimetinib alone if encorafenib is withdrawn from the treatment schedule. The treatment with binimetinib should also be stopped.
How should Binimetinib be taken?• Binimetinib tablets should be taken by mouth twice daily with a precise gap of 12 hours between the two doses.
• Binimetinib can be taken either with or without food. If gastric irritation occurs take binimetinib tablets with food.
• If a dose of binimetinib is missed, take the missed dose as early as possible. Do not take the missed dose if the next scheduled dose is close to 6 hours.
• Never take an extra dose if vomiting occurs while taking binimetinib tablets but continue with the next dose as per the next scheduled time.
What are the side effects of Binimetinib?Gastrointestinal: Nausea, pain in the stomach, loose stools, vomiting, bleeding events in the stomach or rectum
Nervous system: Dizziness, fatigue or weakness
Eye: Visual disturbances, eye damage, blood clot in the eye
Cardiovascular system: High blood pressure
Skin: Rashes, bumps or painful nodules
Others: Anemia, fever, allergic reactions, low levels of sodium in the blood, increased levels of creatinine, creatinine phosphokinase, and liver enzymes
What are the other precautions for Binimetinib?Women of childbearing age should perform a pregnancy test and must take binimetinib only when a pregnancy test shows negative.
What are the Drug Interactions of Binimetinib?Patients should inform the doctor if they are taking any prescription, Over-The-Counter medicines or herbal supplements to avoid dangerous drug interactions.
What are the storage conditions for Binimetinib?• Store binimetinib tablets at room temperature between 20°C and 25°C.
• Protect from excess moisture and heat.
• Keep binimetinib away from children and pets.