This medication is a kinase inhibitor, prescribed for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. It blocks the action of an abnormal protein, which helps in cancer cells multiplication.
PO- The initial recommended dose is 5mg/day.
It comes as a tablet to take by mouth, with or without food.
• Caution should be exercised in patients with history of high blood pressure, thyroid problem, liver impairment, blood clot events, bleeding problems, unhealed wound, who are taking other medications, any allergy, during pregnancy and breastfeeding.
• Avoid drinking grapefruit juice or eat grapefruit while taking this medication.
• Most Common :
Diarrhea, high blood pressure, fatigue, decreased appetite, nausea, loss of voice, hand-foot syndrome (palmar-plantar erythrodysesthesia), weight loss, vomiting, weakness and constipation.
• Miscellaneous : Hypothyroidism, cough, mucosal inflammation, joint pain, mouth ulcer, difficulty in breathing, abdominal pain, headache, pain in extremity, rash, protein in urine, taste disorder, indigestion, difficulty in swallowing, itching, hair loss, redness.
Avoid excess dosage.
Store it at room temperature (20°C to 25°C).
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