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Last Updated : 3/18/2019

General Information on Axicabtagene Ciloleucel

Generic Name : Axicabtagene Ciloleucel

Pronunciation : ax-i-CAB-tay-jeen sye-LO-loo-sel

Latest prescription information about Axicabtagene Ciloleucel. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Axicabtagene Ciloleucel

Yescarta

Overview of Axicabtagene Ciloleucel

Axicabtagene is used for the treatment of cancer called B-cell lymphoma (non-Hodgkin lymphoma) that is resistant to other kinds of therapy in adults.

Why is Axicabtagene Ciloleucel Prescribed? (Indications)

Axicabtagene is used for the treatment of adults with various recurrent or refractory (resistant to treatment) large B-cell lymphomas like diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, and DLBCL arising from follicular lymphoma after trying at least two other kinds of treatment.

It is different from other cancer medicines because it is made from the patient’s white blood cells after modifying to recognize and attack lymphoma cells  

When should Axicabtagene Ciloleucel not to be taken? (Contraindications)

Axicabtagene should not be used in patients :

• If there is an allergy to Axicabtagene

• Not used for any other purpose

What is the dosage of Axicabtagene Ciloleucel?

Axicabtagene is available as a cell suspension for infusion by a catheter placed in a vein for treating large B cell lymphoma. It takes less than 30min for complete infusion.

Dosing of Axicabtagene is based on the number of chimeric antigen receptor-positive T cells.

How should Axicabtagene Ciloleucel be taken?

Axicabtagene should be administered in a well-equipped healthcare facility.

Administer other anticancer drugs like cyclophosphamide and fludarabine before infusion.

Patient’s identity must be verified before infusion.

Premedication with acetaminophen and an H1-antihistamine should be taken to prevent infusion-related side effects.

Patient’s blood will be collected by a process called “leukapheresis” which will help with concentrating the white blood cells.

The patient should get three days of chemotherapy to prepare before the infusion. Patients should be monitored for at least seven days after the infusion.

Healthcare provider will do all the blood tests to follow the progress.

What are the warnings and precautions for Axicabtagene Ciloleucel?

• Monitor for any allergic reactions during the infusion.

• Monitor for signs and symptoms of infection.Monitor complete blood counts for any decrease in cell count.

• Monitor the levels of antibodies and provide replacement therapy in case of decreased globulins.

• If any secondary cancer (malignancy) occurs after treatment with axicabtagene, contact Kite at 1-844-454-KITE.

• Patients are advised to refrain from driving and engaging in dangerous activities such as handling dangerous machinery for at least eight weeks after receiving axicabtagene because it can cause drowsiness, confusion, weakness, memory and coordination problems.

• Blood, organs, tissues and cells donations should be avoided.

• Inform your doctor if you have any neurologic problems like seizures, stroke, or lung or heart or liver or kidney diseases and any recent or active infection.

What are the side effects of Axicabtagene Ciloleucel?

  Gastrointestinal: Nausea, vomiting, constipation, diarrhea, decreased appetite
  Nervous system: Encephalopathy, fatigue(tiredness), headache, tremors, dizziness or lightheadedness
  Cardiovascular: Cardiac arrhythmias (abnormal heart rhythm), hypotension or low blood pressure tachycardia (increased heart rate)
  Respiratory: Cough
  Others: Cytokine release syndrome (symptoms include fever, chills, fatigue, nausea, low blood pressure), febrile neutropenia (low blood count) infections, hypoxia (low levels of oxygen in the body)
  Lab monitoring: Blood tests should be done to monitor the cell counts.
Inform your doctor immediately in case of side effects like fever (100.4°F/38°C or higher), difficulty breathing, chills, confusion, dizziness or lightheadedness, severe nausea, vomiting, or diarrhea, fast or irregular heartbeat, severe fatigue or weakness.

What are the other precautions for Axicabtagene Ciloleucel?

Axicabtagene is not recommended for women who are pregnant.

Breastfeeding women should consult the doctor before using axicabtagene.

Sexually active females of reproductive age group should have a pregnancy test before starting treatment with axicabtagene.

Inform your healthcare provider that you received axicabtagene and show them your axicabtagene patient wallet card.

What are the Drug Interactions of Axicabtagene Ciloleucel?

Axicabtagene may interact with steroids like deflazacort, prednisolone, dexamethasone, hydrocortisone and live vaccines like rotavirus vaccine, smallpox, and zoster vaccines

What are the storage conditions for Axicabtagene Ciloleucel?

Axicabtagene is stored in the vapor phase of liquid nitrogen and supplied in a liquid nitrogen dry shipper. Thaw before using axicabtagene.

Last Updated : 3/18/2019

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