This medication is a selective norepinephrine reuptake inhibitor (SNRI), prescribed for Attention deficit hyperactivity disorder (ADHD). It increases the level of norepinephrine in the brain, which is needed to control behavior.
♦ Contraindicated in patients with narrow-angle glaucoma, severe cardiovascular disease, co-administered with MAOIs or within 14 days of treatment with MAOIs and hypersensitivity.
Dosing of children and adolescents up to 70 kg body weight
Initial: The recommended dose is 0.5 mg/kg and increased after a minimum of 3 days to a target total daily dose of approximately 1.2 mg/kg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. The total daily dose in children and adolescents should not exceed 1.4 mg/kg or 100 mg.
Dosing of children and adolescents over 70 kg body weight and adults Initial: The recommended dose is 40 mg and increased after a minimum of 3 days to a target total daily dose of approximately 80 mg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening.
It comes as a capsule and tablet to take by mouth, with or without food.
Caution should be exercised in patients with history of depression or bipolar disorder, suicidal thoughts, high or low blood pressure, seizures, liver diseases, heart problems, stroke, blood or bleeding problems, seizures, trouble urinating, Raynaud syndrome, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, drowsiness, lightheadedness or fainting, do not drive a car or operate machinery and sit up or stand slowly from bed while taking this medication.
Avoid alcohol consumption.
♦Monitor blood pressure and heart rate regularly while taking this medication.
Child and Adolescent :
Gastrointestinal : Liver disease, abdominal pain, vomiting and nausea.
General: Fatigue, irritability and unexpected therapeutic response.
Metabolism: Loss of appetite and decreased weight.
Central Nervous System: Headache, drowsiness and dizziness.
Gastrointestinal: Abdominal pain, vomiting, nausea and constipation.
Psychiatric: Mood changes.
Gastrointestinal: Dry mouth, nausea, constipation, abdominal pain, indigestion and vomiting.
General: Fatigue, chills, unexpected therapeutic response and stress.
Metabolic: Decreased appetite and weight.
Central Nervous System: Dizziness, drowsiness, tingling, sinus, headache and tremor.
Psychiatric: Sleeplessness, decreased libido and sleep disorder.
Urinary: Urinary hesitation and/or urinary retention and painful urination.
Genitourinary: Impotence, painful menstrual periods, delayed ejaculation and irregular periods.
Skin: Excessive sweating and rash.
Vascular: Hot flushes.
Avoid excess dosage.
Children and teenagers may develop with increased risk of suicidal thoughts, watch them carefully.
Rarely this medication may cause prolonged, painful erection. If it so consult with your doctor.
Monitor heart rate, blood pressure and liver function while taking this medication.
Store it at controlled room temperature (25°C).
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