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General Information on Apremilast

Generic Name : Apremilast

Pronunciation : a-PREM-i-last

Latest prescription information about Apremilast. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Apremilast

Otezla

Overview of Apremilast

Apremilast is an inhibitor of the enzyme phosphodiesterase 4 (PDE4) indicated for the treatment of adult patients with joint pain due to arthritis.

Why is Apremilast Prescribed? (Indications)

Apremilast acts by inhibiting the enzyme named phosphodiesterase 4 (PDE4). 

When should Apremilast not to be taken? (Contraindications)

Apremilast should not be used in patients

•If there is an allergy to apremilast

•Below 18 years

What is the dosage of Apremilast?

Apremilast is available in the form of tablets of doses 10 mg, 20 mg or 30 mg to be taken daily by mouth for joint pain due to psoriasis.

The dose should be increased gradually to avoid gastric irritation and acidity.

How should Apremilast be taken?

Apremilast tablets should be given according to this given schedule:

Day 1: one 10 mg tablet in the morning
Day 2: one 10 mg tablet in the morning and one 10 mg tablet in the evening
Day 3: one 10 mg tablet in the morning and one 20 mg tablet in the evening
Day 4: one 20 mg tablet in the morning and one 20 mg tablet in the evening
Day 5: one 20 mg tablet in the morning and one 30 mg tablet in the evening
Day 6 and thereafter: 30 mg 2 tablets daily

What are the warnings and precautions for Apremilast?

•Patients are advised to be alert for the emergence of symptoms of depression, suicidal thoughts or any other mood changes and if such changes occur to contact with their doctor

•Carefully weigh the risks and benefits of apremilast in patients with a history of depression and/or suicidal thoughts.

•Weight should be monitored regularly as apremilast can decrease weight. If significant weight loss occurs, evaluate weight loss and consider discontinuation of apremilast

What are the side effects of Apremilast?

  Gastrointestinal: Nausea, vomiting, diarrhea, upper abdominal pain, dyspepsia, decreased appetite

  Nervous system: Headache

  Respiratory: Inflammation of Nose and pharynx, upper respiratory tract infection

  Skin: Rash, allergies

  Lab abnormalities: Weight should be monitored regularly

What are the other precautions for Apremilast?

• Caution should be exercised when using apremilast in a nursing woman.

• The recommended dose is one tablet 30 mg daily in case of severe kidney damage.

• In case of overdose with apremilast, patients should seek immediate medical help.

• Symptomatic and supportive care should be taken in this case.

What are the Drug Interactions of Apremilast?

Apremilast effect can be decreased by rifampin, phenobarbital, and carbamazepine.

What are the storage conditions for Apremilast?

Apremilast tablets should be stored below 30 °C (86°F). Protect from excess moisture

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