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Antihemophiliac factor - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Antihemophiliac factor

Generic Name : Antihemophiliac factor
Pronunciation : ant ee hee moe FIL ik FAK tor
Latest prescription information about Antihemophiliac factor. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y44.7 | Therapeutic Classification : Antihemophilics
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Trade Names/Brand Names of Antihemophiliac factor

India- Fanhdi, Haemoctin Sdh Factor Viii, Hemofil-M,Monoclate-P.
International- Advate, Xyntha, Helixate NexGen, Helixate FS, Bioclate, Kogenate FS, Recombinate, ReFacto, Wilate, Alphanate, Hemofil M Method M Monoclonal Purified, Humate-P, Koate-DVI, Monarc-M Method M Monoclonal Purified, Monoclate-P.
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Why is Antihemophiliac factor Prescribed? (Indications)

This medication is an essential blood-clotting factor, prescribed for controlling and preventing bleeding episodes in people with low levels of factor VIII (hemophilia A) and AHG deficiency. This product contains a man-made form of factor VIII, also called antihemophilic factor. This temporarily replaces the missing factor VIII, a protein (clotting factor) that is normally in the blood, so that the blood can clot and the bleeding can stop. Glycopegylated-antihemophilic factor was approved by the FDA in February 2019 which has an extended half-life.  

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When should Antihemophiliac factor not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Antihemophiliac factor?

IV- The recommended dose is 5 10 U/kg, repeated 6 to 12 hourly.

How should Antihemophiliac factor be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein. Warm diluent (Sterile Water for Injection, USP) and concentrate (Alphanate (antihemophilic factor) ) to at least room temperature (but not above 37 C).

What are the warnings and precautions for Antihemophiliac factor?

• Caution needed in pregnant and breastfeeding women.

This medication should not be used to treat von Willebrand disease.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Antihemophiliac factor?

   Central Nervous System : Dizziness and headache.
   Skin : Itching, flushing of face, hives, swelling of face, lips, tongue, or throat, burning/redness/irritation at the injection site and unusual bruising or bleeding.
   Gastrointestinal : Stomach upset, stomach pain, loss of appetite, nausea, vomiting and sore throat.
   Miscellaneous : Fever, chills, difficulty in breathing, fast heart beat and chest tightness.

What are the other precautions for Antihemophiliac factor?

Avoid excess dosage. Should not be administered at a rate exceeding 10 mL/minute. Rapid administration of a Factor VIII concentrate may result in vasomotor reactions.

What are the storage conditions for Antihemophiliac factor?

Store it in refrigerator (2 to 8C), do not freeze it. May be stored at room temperature not to exceed 30 C for up to 2 months.




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