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Last Updated : 3/12/2018

General Information on Angiotensin II

Generic Name : Angiotensin II

Pronunciation : an-jee-oh-TEN-sin-too

Latest prescription information about Angiotensin II. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Antihypotensives

Trade Names/Brand Names of Angiotensin II

Giapreza

Overview of Angiotensin II

Angiotensin II injection for intravenous use has been approved by US FDA in December 2017 for treating low blood pressure in adult patients with septic or distributive shock.

Why is Angiotensin II Prescribed? (Indications)

Angiotensin II is a synthetic human vasoconstrictor which is prescribed for increasing blood pressure in adult patients to treat low blood pressure with septic shock or distributive shock.

Angiotensin II also stimulates the release of another hormone known as aldosterone which promotes the retention of sodium in the kidney and contributes to the rise in blood pressure.
 

When should Angiotensin II not to be taken? (Contraindications)

Angiotensin II should not be used in patients with

Allergy to angiotensin II
Children below 18 years of age

What is the dosage of Angiotensin II?

The recommended initial dose of angiotensin II is 20 ng/kg/min administered as a continuous infusion directly into the vein, preferably through a central venous line.

Maintenance dose: 40 ng/kg/min
Maximum dose: 80 ng/kg/min

How should Angiotensin II be taken?

Angiotensin II injection should be diluted with 0.9% sodium chloride solution and should be administered intravenously.
The diluted solution should be prepared to achieve a final concentration of either 10,000 ng/ml in fluid restricted patients or 5000 ng/ml.
The unused solution should be discarded.

What are the warnings and precautions for Angiotensin II?

Patients should be monitored for arterial and venous thrombotic or thromboembolic events (clots in the arteries or veins) particularly deep vein thrombosis.
Preventive steps should be taken to prevent venous thromboembolism.
Patients should be advised to report to the emergency center in case of abnormal heartbeat, shortness of breath, swelling of arms or legs or coughing up blood.

What are the side effects of Angiotensin II?

Deep vein thrombosis
Low platelet levels
Increased heartrate
Fungal infection
Delirium
Acidosis
High blood sugar level
Peripheral ischemia (reduced blood flow to the limbs)

What are the other precautions for Angiotensin II?

An overdose of angiotensin II results in severe hypertension which requires strict monitoring and supportive medical care.

What are the Drug Interactions of Angiotensin II?

Angiotensin-converting enzyme inhibitor drugs such as lisinopril, captopril, enalapril, ramipril may increase the response to angiotensin II.
Angiotensin II receptor blocker drugs such as losartan, valsartan, telmisartan, candesartan and olmesartan decrease the action of angiotensin II injection when administered together ; the combination should be avoided.

What are the storage conditions for Angiotensin II?

Angiotensin II vials should be stored in a refrigerator at 2C to 8C.
The prepared diluted solution should be discarded after 24 hours irrespective of whether it is kept at room temperature or in a refrigerator.

Last Updated : 3/12/2018
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