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Agalsidase - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Agalsidase

Generic Name : Agalsidase
Pronunciation : aye-GAL-sih-dace
Latest prescription information about Agalsidase. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Endocrine and Metabolic Agents
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Trade Names/Brand Names of Agalsidase

India- Galazyme, Gastica plus, Leno.
International- Fabrazyme, Replagal.
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Why is Agalsidase Prescribed? (Indications)

Agalsidase is prescribed for treating patients with Fabry disease; a rare genetic disorder occurs due to a deficiency of alpha-galactosidase-A (an enzyme responsible for breaking down fat). Agalsidase provides the enzyme alpha-galactosidase A to the body.

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When should Agalsidase not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Agalsidase?

The recommended dosage is 1.0 mg/kg body weight infused every 2 weeks as an IV infusion.

How should Agalsidase be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Agalsidase?

• Caution should be exercised in patients with history of heart or lung problems, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Agalsidase?

   Most Common : Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, itching, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness.
   Infections : Upper respiratory tract infection and fungal infection.
   Central Nervous System : Anxiety and depression.
   Respiratory : Cough, difficulty in breathing and wheezing.

What are the other precautions for Agalsidase?

Avoid excess dosage.

What are the storage conditions for Agalsidase?

Store it in refrigerator (2-8C). Do not freeze it.

Last Updated : Jul 2018



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