Do you know what Osama bin Laden and John F Kennedy have in common? They are both Addisonians!
Addison's disease is a rare endocrine disorder which occurs when the adrenal gland fails to produce the cortisol hormones -glucocorticoids and mineralocorticoids. Also called
hypocortisolism or adrenal insufficiency, this life-threatening condition occurs at a frequency of 1 in 100,000, especially in those between the ages 30 to 50. However, it is also known to affect children.
Addison’s disease derives its name from the British physician
Dr. Thomas Addison who was the first to describe it in 1855.
The adrenal glands, situated atop the kidneys, are composed of an interior
medulla and an outer
cortex. The medulla produces adrenaline-like hormones while the
cortex produces the
corticosteroids (glucocorticoids and mineralocorticoids) and the male sex hormones – the androgens. When the adrenal cortex fails to function, Addison’s disease results.