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Glomerulonephritis Types - Membrano proliferative Glomerulonephritis
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Glomerulonephritis Types
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Glomerulonephritis Types | |
About Membranoproliferative Glomerulonephritis |
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Antibody Mediated
Membranoproliferative Glomerulonephritis Membranoproliferative, or mesangiocapillary, glomerulonephritis (MPGN) is a chronic progressive glomerulonephritis that occurs in older children and adults. Circulating immune complexes have been identified in 50% of patients and activation of the complement system with hypocomplementemia, is a hallmark of MPGN. Idiopathic MPGN has several distinct histopathologic and immunopathologic features and three variants have been described.  Type I MPGN characterized by mesangial and subendothelial immune deposits. Type II MPGN (dense deposit disease) characterized by interrupted linear deposits in the lamina densa of the basement membrane. Type III MPGN, an uncommon variant, characterized by features of both type I MPGN and membranous GN, or by disurption of the glomerular basement membrane with accumulation of new basement membrane material arranged in layers. Clinical Course Patients with MPGN may present with the nephrotic syndrome, an abnormal urinary sediment with non-nephrotic proteinuria or with acute nephritis. The diagnosis is suspected when serum complement levels are depressed. Antibody Mediated Type I MPGN:  Is the most frequent primary MPGN Is also often associated with
systemi disease, infection and neoplasms. Membranoproliferative glomerulonephritis secondary to cyroglobulinemia is strongly associated with Hepatitis C virus infection. The nephrotic syndrome is the most common presenting illness. Type I MPGN is a slowly progressive disease; in 30-40% of patients the disease remains stable despite persistent nephrotic range proteinuria. Median survival, free of renal failure in both children and adults ranges from 9 to 12 years. In type II MPGN: Acute nephritis or recurrent macroscopic hematuria are the most common presentations. Most patients with type II MPGN are younger than 20 years of age, have more persistent C3 depression and more commonly present with nephritis. Approximately 20% of patients remain stable for many years and median survival, free of renal failure ranges from 5 to 10
years. |
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Posted by:
breanna
Posted on: 02/04/2010 i was diagnosed with mpgn type 2 at 4 yrs old... it all started with a persistant cold. My mom always thought i was pale but, she had no idea until she found me lethargic on the floor.. my blood pressure was sky high. my urine was black. my 14 yr treatment consisted of aggressive doses of prednisone and blood pressure medication. i also give all the credit in the world to the doctors and staff at the Motts childrens hospital in ann arbor michigan.
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Posted by:
Tamara Harchanko(Guest)
Posted on: 11/13/2008 my stepmom has minimal change disease- she also has rhem.arthritis- last week relapsed into MCD- her ankles are swolen to painful- Is there anybody who knows what foods are for her to eat???? She also suffers from celiac and is under 100 lbs- Please help!!
Posted by:
breanna
Posted on: 07/07/2008 to whom it may concern... I am a 20 year old servivor of MPGN. i was diagnosed at 4 and have now been in remission for 4 years. ive never had a transplant, and although i was very close to it ive never been on dialysis.
Posted by:
no1keene
Posted on: 08/21/2008 Hi bree. Glad to hear you are a survivor of MPGN. I am from ireland and my brothers little girl took this disease 9 weeks ago. She is on dialayis ever day and we are very concerned for her. I would be greatly obliged and grateful to hear the full story of your experiences and any advice you could offer me. Thankyou for you time and take care, colin |
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