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Risk of Low Platelet Counts Influenced by Sterilization Method for Hemodialysis Dialyzer Membrane
"Adverse device reactions to hemodialysis treatments are uncommon but can still occur in today's era of hemodialysis membranes and technology. During hemodialysis treatment, patients are exposed to a variety of components of the dialysis circuit and could have an adverse reaction to blood tubing, dialyzer membranes [used in the dialysis machines], and dialysis solutions," according to background information in the article. "Thrombocytopenia is not widely recognized as a potential dialyzer-related complication. Following the observation of significant thrombocytopenia among 20 patients undergoing hemodialysis in a single dialysis unit after the introduction of dialyzers sterilized by electron beam (e-beam), a larger investigation was undertaken."
Mercedeh Kiaii, M.D., F.R.C.P.C., of the University of British Columbia, Vancouver, Canada, and colleagues conducted a study to determine the prevalence and cause of thrombocytopenia in patients undergoing hemodialysis in British Columbia and southern Alberta province between April 2009 and November 2010. Retrospective analyses of historical patient, laboratory, and dialyzer data predating conversion to e-beam dialyzers were undertaken, with prospective collection of predialysis and postdialysis platelet counts before and after the change from e-beam to non-e-beam sterilized dialyzers in September 2009. Significant thrombocytopenia was defined as post-dialysis treatment platelet count of less than 100 x 103/ĩL and a postdialysis decrease in platelet count of more than 15 percent.
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