login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Researchers Identify Genetic Mutations for Hereditary Diffuse Gastric Cancer
June 04, 2007 at 3:56 PM
Cancer News
According to background information in the article, gastric cancer is the second most common cause of cancer death worldwide. There are two major variants of this cancer: an intestinal type and a diffuse type. "A decline in the overall incidence of gastric cancer can be attributed primarily to a decrease of the intestinal variant of gastric cancer with the diffuse type remaining stable or possibly even increasing."
Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the gene CDH1, and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer. "The identification of CDH1 mutations offers the opportunity of cancer risk-reduction strategies for unaffected at-risk individuals," the authors write.
Pardeep Kaurah, M.Sc., of the BC Cancer Agency, Vancouver, and colleagues conducted a study to assess the frequency of mutations in the CDH1 gene and whether these mutations occurred due to independent mutational events or common ancestry.
The study included 38 families diagnosed clinically with HDGC, who were analyzed for CDH1 mutations. Twenty-six families had at least two gastric cancer cases with one case of diffuse gastric cancer in a person younger than 50 years; 12 families had either a single case of diffuse gastric cancer diagnosed in a person younger than 35 years or multiple cases of diffuse gastric cancer diagnosed in persons older than 50 years.
|
|
|
More News on: Gastric Cancer, Cancer and Homeopathy, Cancer Facts, Cancer, Von Recklinghausen's Disease, Crigler-Najjar Syndrome, Gilberts Syndrome, McArdle Disease
 Comment & Contribute
|
|
ClaireG(Guest)
09/16/2011
My husband died of gastric cancer [of the cardia] at 35. I would like to know how easy the test for this CDH1 gene as I would like to know if our son is at risk. Could any one help me with this question? claire
Reply |
Forward
|
Medwonders Health Network
- Health News Index
 | Quiz on Cancer Looking for information on cancer? Go through medindia's Cancer quiz. 
|
- News Quick Links
 |
Cancer
Complete Medindia Resources
|
| News Categories: |
| » | Mystery of 'Disappearing' Tweets Solved |
| » | 'Slut Walks' Attract Thousands in Brazil |
| » | Enthusiasm for Tattoos High Among Women |
| » | Individuals' Brains 'Tick Together' If They Have Strong Emotions |
| » | Keeping Emotions in Check and Being Resilient Helps to Remain Satisfied With Life |
| More Life Style News | |
|
