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Dichloroacetate Effective Against Aggressive Brain Cancer
The study published in Wednesday's online issue of the journal Science Translational Medicine showed tumours responded to DCA by changing their metabolism. Because DCA has a unique way of killing cancer cells, the new findings represent progress in a new area of cancer research that may stunt growth of tumours without harming healthy cells.
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma, wrote Evangelos D. Michelakis of the University of Alberta and his colleagues.
Freshly isolated glioblastomas from 49 patients showed mitochondrial hyperpolarization, which was rapidly reversed by DCA. In a separate experiment with five patients who had glioblastoma, they prospectively secured baseline and serial tumor tissue, developed patient-specific cell lines of glioblastoma and putative glioblastoma stem cells, and treated each patient with oral DCA for up to 15 months. There too the researchers tasted success.
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More News on: Parkinsons Disease, Cancer and Homeopathy, Parkinsons Disease Surgical Treatment, Cancer Facts, Cancer, Tattoos A Body Art, Brain, Brain Facts, Ataxia
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07/04/2010
I would also like to know if this is something that can help my daughter. She has a right temporal lobe astrocytoma [brain tumor]. She had an operation to remove it in 2007 and it was not successful. She may have also been exposed to CJD while on the operating table. Her tumor has now just shown signs of early progression (where they operated). Is this something that could help my daughter. Please help me find a way to save her.
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just_in_case(Guest)
10/20/2010
Not sure?! I KNOW that DCA does not work well with sarcoma's??? BUT it kicks the snot out of all other cancers! My wife is part of the U of A human trials and in 4 months she has seen 45% regression with just DCA and vitamins B1, "greens", pommagranate extract. green tea extract, vit C and and calcium...NO SUGAR NO FRUIT NO SUGAR NO FRUIT..
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Caregiver
02/29/2012
Where does one get it in India?
For God's sake, give us information on that count.
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ddearborn(Guest)
05/22/2010
Hmmm As always the story ends when once we find out how. Translation "once we find out how to patent something and make money" then and only then will the public get access. You see modern medicine is much more concerned with the process rather than the outcome. It is all about the money. The fact that something works is irrelevant. It cannot be patented, it is discarded, or worse hidden away.
Robmxa(Guest)
05/22/2010
MaxStravich(Guest)
05/31/2010
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