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Dichloroacetate Effective Against Aggressive Brain Cancer

by Gopalan on  May 13, 2010 at 9:17 AM Cancer News   - G J E 4
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Orphan drug dichloroacetate (DCA) has been found effective against aggressive brain cancer in a small Canadian study. Orphan drugs are meant to treat rare medical conditions. DCA is now used to treat a rare enzyme disorder in children, but researchers have found it useful in brain tumor too.
 Dichloroacetate Effective Against Aggressive Brain Cancer
Dichloroacetate Effective Against Aggressive Brain Cancer

The study published in Wednesday's online issue of the journal Science Translational Medicine showed tumours responded to DCA by changing their metabolism. Because DCA has a unique way of killing cancer cells, the new findings represent progress in a new area of cancer research that may stunt growth of tumours without harming healthy cells.

"Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma," wrote Evangelos D. Michelakis of the University of Alberta and his colleagues.

Freshly isolated glioblastomas from 49 patients showed mitochondrial hyperpolarization, which was rapidly reversed by DCA. In a separate experiment with five patients who had glioblastoma, they prospectively secured baseline and serial tumor tissue, developed patient-specific cell lines of glioblastoma and putative glioblastoma stem cells, and treated each patient with oral DCA for up to 15 months. There too the researchers tasted success.

In four of the five glioblastoma patients, there was no further brain cancer growth after initial treatment. Follow-up studies on cells taken from these patients showed that DCA killed cancer cells.

Nerve damage can occur at higher doses of DCA, but the study's authors suggest that at the dose used in the study, the drug might be able to stem tumor growth without serious side-effects.

"We can conclude that DCA is possibly safe and maybe clinically effective in some patients," said Dr. Michelakis.

"Due to the small size of this study we can't make more speculations. However, these early findings are enough to create enough enthusiasm and inspiration and momentum to go to the next step, which involves multi-centre trials." 

Funding for the Alberta University research was raised by a concerned community, apart from what could be obtained from federal agencies and from the university itself - pharmaceutical companies were not too keen on further research on DCA as it was a generic drug with no patent on it.

"We challenged the dogma that without industry you can't actually test drugs on human beings," Michelakis noted with satisfaction.
If researchers can understand how the tumour adapts its glucose metabolism to reap survival advantages, then DCA could be used in combination with other therapies to extend the lives of glioblastoma patients,  Dr. Abhijit Guha, a professor of surgery at the University of Toronto, told CBC News. Currently, their average survival is 14 to 16 months with standard treatments.







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I would also like to know if this is something that can help my daughter. She has a right temporal lobe astrocytoma [brain tumor]. She had an operation to remove it in 2007 and it was not successful. She may have also been exposed to CJD while on the operating table. Her tumor has now just shown signs of early progression (where they operated). Is this something that could help my daughter. Please help me find a way to save her.
lambermon Sunday, July 04, 2010
Not sure?! I KNOW that DCA does not work well with sarcoma's??? BUT it kicks the snot out of all other cancers! My wife is part of the U of A human trials and in 4 months she has seen 45% regression with just DCA and vitamins B1, "greens", pommagranate extract. green tea extract, vit C and and calcium...NO SUGAR NO FRUIT NO SUGAR NO FRUIT..
just_in_case Wednesday, October 20, 2010
Where does one get it in India? For God's sake, give us information on that count.
Caregiver Wednesday, February 29, 2012
Hmmm

As always the story ends when once we find out how. Translation "once we find out how to patent something and make money" then and only then will the public get access. You see modern medicine is much more concerned with the process rather than the outcome. It is all about the money. The fact that something works is irrelevant. It cannot be patented, it is discarded, or worse hidden away.

ddearborn Saturday, May 22, 2010
You can get and use DCA. I have used it for a year. I have had two tumor reductions and 4 stable disease, no change in tumor size in 6 CT scans over the last year. I am fine and have no symptoms from my metastatic colon cancer. I have had no chemo other than DCA. It works for me.
Robmxa Saturday, May 22, 2010
Where do you get it from, and what dose are you taking? We are looking into using DCA for my husband's brain tumor.
MaxStravich Monday, May 31, 2010

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