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Ziprasidone

Latest prescription information about Ziprasidone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Ziprasidone
Pronunciation : zi-PRAS-i-done
Therapeutic Classification : Antipsychotics
ICD Code : Y49.5
Trade Name(s): 
India- Azona, Zipris, Zipsydon.
International- Geodon.
Why it is prescribed (Indications) : 
This medication is an antipsychotic agent, prescribed for schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). It regulates certain chemical activities in brain, which is responsible for thinking and behavior. 
When it is not to be taken (Contraindications): 
Contraindicated in patients with history of heart diseases, elderly patients with dementia, known hypersensitivity to this drug.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: PO- Schizophrenia: As HCl: ≥18 years: Initial: 20 mg twice daily, may increase slowly to 80 mg twice daily, if needed. Maintenance: 20 mg twice daily.
How it should be taken : 
It comes as a capsule to take by mouth. It is usually taken twice a day with food.
Warnings and Precautions : 
*Caution needed for patients with history of Alzheimer's disease, coronary artery disease, irregular heartbeat, low blood pressure, severe dizziness/fainting, diabetes (including family history), stroke, seizures, Neuroleptic malignant syndrome, obesity, swallowing problems, pneumonia, low white blood cell count, liver or kidney impairment, during pregnancy and breastfeeding.
*Patient may develop an increased risk of QT prolongation, if it so, stop the medication.
*It may make you drowsy or dizzy, do not drive a car or operate machinery while taking this medication.
*Monitor ECG in patients who show symptoms of torsades de pointes (e.g. syncope, dizziness, and palpitations).
*If on concurrent diuretic therapy monitor the level of serum electrolytes.
Side Effects : 
Most Common- Nausea, vomiting, drowsiness, runny nose, weakness.
Central Nervous System- Headache, lethargy, weakness, extra pyramidal syndrome, muscle stiffness, movement disorder, tremor, paralysis and twitching.
Heart- Fast heart rate, high blood pressure and postural low blood pressure.
Gastrointestinal- Loss of appetite, difficulty in swallowing, indigestion and rectal bleeding.
Hormone- Abnormally high levels of prolactin in the blood.
Genitourinary- Absence of menstrual cycle, impotence and breast enlargement in males.
Metabolic- Weight gain.
Skin- Rash.
Respiratory- Respiratory tract infection and cough.
Potentially Fatal- Blood disorder and life- threatening neurological disorder.
Other Precautions : 
*Monitor sugar level regularly in diabetic patients or patients at risk of developing diabetes.
*Monitor complete blood count regularly in patients with pre- existing blood disorder.
Storage Conditions : 
Injection: Store at 15-30°C. Protect from light. Keep this medication in an airtight container, and out of reach of children. Store it at room temperature.

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Member Comments ( 1 )
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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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