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Mexiletine

Latest prescription information about Mexiletine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Mexiletine
Pronunciation : mex-IL-e-teen
Therapeutic Classification : antiarrhythmics
Trade Name(s): 
International- Mexitil Cap, Mexitil Inj.
Why it is prescribed (Indications) : 
This medication is used to treat irregular heart rhythms (arrhythmias) and maintain a normal heart rate. It is an antiarrhythmic. It blocks certain electrical signals in the heart to stabilize the heart rhythm.

When it is not to be taken (Contraindications): 


Contraindicated in patients with cardiogenic shock, 2nd- or 3rd-degree AV block (unless the patient has a pacemaker).

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
IV- The recommended dose is 100-200mg, over 10 minutes (1mg/min) infusion.
PO- The recommended dose is 150-200mg, three times a day with meals.
How it should be taken : 
It comes as a capsule to take by mouth with food, either twice or thrice depending upon patient’s condition. It is also administered as an infusion at the rate of 1 mg/min.
Special Instruction : 
*Caution needed for patients with history of acute MI, sinus node dysfunction, conduction defects, slow heart rate, low blood pressure, heart failure, liver impairment, pregnancy.
*Monitor ECG and BP.
*Correct electrolyte imbalance prior to and during therapy.
*It may cause dizziness, avoid driving a car or operate machines, or other unsafe tasks.
Side Effects : 
Heart- Palpitations, chest pain, increased heart rhythm and heart failure.
Central Nervous System- Dizziness, lightheadedness, tremor, nervousness, coordination difficulties, headache, changes in sleep habits, weakness, tingling, numbness, fatigue, speech difficulties, confusion, depression and drowsiness.
Liver- Increased liver enzymes and liver damage.
Skin- Rash.
Eye and ENT- Blurred vision, visual disturbances, ringing in ears, and uncontrolled movement of the eyes.
Gastrointestinal- Nausea, vomiting, heartburn, diarrhea, constipation, changes in appetite, dry mouth, abdominal pain, cramps, or discomfort.
Blood- Decrease in white blood cells and platelets.
Musculoskeletal- Muscle pain.
Respiratory- Difficulty in breathing.
Miscellaneous- Non-specific swelling, fever and hypersensitivity.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store at 25°C. Store it in an airtight container and keep away from children.

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