This medication is used to treat irregular heart rhythms (arrhythmias) and maintain a normal heart rate. It is an antiarrhythmic. It blocks certain electrical signals in the heart to stabilize the heart rhythm.
Mexiletine is also approved to treat non-dystrophic myotonia in adult patients whose muscles do not relax immediately after contraction resulting in muscle stiffness, pain, disability, and frequent falls.
Contraindicated in patients with cardiogenic shock, 2nd- or 3rd-degree AV block (unless the patient has a pacemaker).
IV- The recommended dose is 100-200mg, over 10 minutes (1mg/min) infusion.
PO- The recommended dose is 150-200mg, three times a day with meals.
It comes as a capsule to take by mouth with food, either twice or thrice depending upon patients condition. It is also administered as an infusion at the rate of 1 mg/min.
Caution needed for patients with history of acute MI, sinus node dysfunction, conduction defects, slow heart rate, low blood pressure, heart failure, liver impairment, pregnancy.
Monitor ECG and BP.
Correct electrolyte imbalance prior to and during therapy.
It may cause dizziness, avoid driving a car or operate machines, or other unsafe tasks.
Palpitations, chest pain, increased heart rhythm and heart failure.
Central Nervous System: Dizziness, lightheadedness, tremor, nervousness, coordination difficulties, headache, changes in sleep habits, weakness, tingling, numbness, fatigue, speech difficulties, confusion, depression and drowsiness.
Liver: Increased liver enzymes and liver damage.
Eye and ENT: Blurred vision, visual disturbances, ringing in ears, and uncontrolled movement of the eyes.
Gastrointestinal: Nausea, vomiting, heartburn, diarrhea, constipation, changes in appetite, dry mouth, abdominal pain, cramps, or discomfort.
Blood: Decrease in white blood cells and platelets.
Musculoskeletal: Muscle pain.
Respiratory: Difficulty in breathing.
Miscellaneous: Non-specific swelling, fever and hypersensitivity.
Avoid excess dosage.
Store at 25°C. Store it in an airtight container and keep away from children.
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