Trade Names/Brand Names :
Why it is prescribed :
This medication is a bisphosphonate, primarily used for prevention and treatment of osteoporosis in men and postmenopausal women. It is also used for Paget's disease and osteoporosis caused by steroid treatment. It reduces the amount of calcium released from the bones into the blood.
When it is not to be taken (Contraindications):
Contraindicated in patients with hypersensitivity, decreased level of calcium in blood, esophageal abnormalities and factors which delay esophageal emptying, severe kidney impairment, inability to stand or sit upright for more than half an hour, during pregnancy and breastfeeding.
Category C :
Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.
Dosage & When it is to be taken (Indications):
PO: The recommended dose is 5 to 10mg once daily or 35 to 70mg tablet once weekly.
How it should be taken :
It comes as a tablet, should be taken on an empty stomach.
Warnings and Precautions :
•Caution needed in patients with history of upper gastrointestinal disorders (discontinue if symptoms worsen); ulcers and active gastrointestinal bleeding.
•Correct vitamin D and calcium deficiency before starting therapy.
•Not recommended for use in patients with CrCl <35 ml/min.
•Proper dental care is important while taking this medication.
•Do not drive a car or operate machinery, avoid alcohol and smoking while taking this medication.
Side Effects :
• Postmenopausal women
Abdominal pain, nausea, indigestion, constipation, diarrhea, flatulence, acid regurgitation esophageal ulcer, vomiting, difficulty in swallowing and stomach inflammation.
Bone, muscle/joint pain, muscle cramp and osteonecrosis of the jaw.
• Central Nervous System
Headache and dizziness.
Acid regurgitation, flatulence, heart burn, diarrhea, abdominal pain and nausea.
• Body as a Whole
Hypersensitivity reactions, muscle pain, uneasiness, weakness and rarely fever.
• Central Nervous system
Dizziness and fainting.
Rash (occasionally with photosensitivity), itching, hair loss, rarely severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.
Other Precautions :
It may cause severe bone, muscle, or joint pain.
Storage Conditions :
Store it at room temperature and in an airtight container. Keep away from children and pets.