Alendronate - Drug Information

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General Information on Alendronate

Generic Name : Alendronate

Pronunciation : a-LEN-droe-nate

Latest prescription information about Alendronate. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y57.9 | Therapeutic Classification : Bone Enhancers

Why is Alendronate Prescribed? (Indications)

This medication is a bisphosphonate, primarily used for prevention and treatment of osteoporosis in men and postmenopausal women. It is also used for Paget's disease and osteoporosis caused by steroid treatment. It reduces the amount of calcium released from the bones into the blood. 

When should Alendronate not to be taken? (Contraindications)

Contraindicated in patients with hypersensitivity, decreased level of calcium in blood, esophageal abnormalities and factors which delay esophageal emptying, severe kidney impairment, inability to stand or sit upright for more than half an hour, during pregnancy and breastfeeding.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Alendronate?

PO: The recommended dose is 5 to 10mg once daily or 35 to 70mg tablet once weekly.

How should Alendronate be taken?

It comes as a tablet, should be taken on an empty stomach.

What are the warnings and precautions for Alendronate?

Caution needed in patients with history of upper gastrointestinal disorders (discontinue if symptoms worsen); ulcers and active gastrointestinal bleeding.
Correct vitamin D and calcium deficiency before starting therapy.
Not recommended for use in patients with CrCl <35 ml/min.
Proper dental care is important while taking this medication.
Do not drive a car or operate machinery, avoid alcohol and smoking while taking this medication.

What are the side effects of Alendronate?

  Postmenopausal women
  Gastrointestinal: Abdominal pain, nausea, indigestion, constipation, diarrhea, flatulence, acid regurgitation esophageal ulcer, vomiting, difficulty in swallowing and stomach inflammation.
   Musculoskeletal : Bone, muscle/joint pain, muscle cramp and osteonecrosis of the jaw.
  Central Nervous System : Headache and dizziness.
  ENT: Taste perversion.
  Men
  Gastrointestinal : Acid regurgitation, flatulence, heart burn, diarrhea, abdominal pain and nausea.
  Body as a Whole : Hypersensitivity reactions, muscle pain, uneasiness, weakness and rarely fever.
  Central Nervous system: Dizziness and fainting.
  Skin: Rash (occasionally with photosensitivity), itching, hair loss, rarely severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.
  Eye: Eye inflammation.

What are the other precautions for Alendronate?

It may cause severe bone, muscle, or joint pain.

What are the storage conditions of Alendronate?

Store it at room temperature and in an airtight container. Keep away from children and pets.

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JagdishK 

Hi! I been advised by doctor to take osteofos 70 Mg I have been taking the same for past 10 years with a break of max one year can this have some side effects to my body though I don't feel any difference in my body. I was advised Osteofos 70mg due to a tallis bone fracture which didn't heel correctly it still pains while getting up after long sitting or sleeping.

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