Generic Name : Adefovir dipivoxil Pronunciation : a-DEF-oh-vir dye-piv-OX-il Therapeutic Classification : Antivirals ICD Code : Y41.5
India- Adfovir, Adheb.
International- Hepsera. Why it is prescribed (Indications) :
This medication is a reverse transcriptase inhibitor (ntRTI), prescribed for hepatitis B, and herpes simplex virus infection. It slows the growth of HBV by blocking reverse transcriptase, an enzyme that is helpful for viral reproduction. When it is not to be taken (Contraindications):
Contraindicated in patients who are taking tenofovir, liver enlargement, and hypersensitivity.
Dosage & When it is to be taken :
Adult- PO -The recommended dose is 10mg/day. How it should be taken :
It comes as a tablet to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with history of kidney, liver diseases, abnormal liver function tests, liver transplant, HIV infection, obesity, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.
* It should not be used in children less than 12 years old.
* Monitor kidney and liver functions regularly while taking this medication.
* If condition worsens stop the medication immediately. Side Effects :
Most Common - Weakness, headache, abdominal pain, diarrhea, nausea, indigestion, flatulence, increased creatinine, and decrease in blood phosphate level.
Gastrointestinal - Inflammation of pancreas.
Muscuskeletal - Muscle pain and softening of bones.
Genitourinary - Kidney failure and Fanconi syndrome.
* It does not stop the spread of HBV to others; avoid sexual contact, sharing of needles and injection supplies. Storage Conditions :
Store it in room temperature (25°C), and in an airtight container.
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