ALL is the commonest of childhood cancers and accounts for almost 25% of all cancers in children below the age of 15 years.
Acute lymphoblastic leukemia has, over the last decade or two, evolved and served as an ideal model for diagnosing and treating cancers in children as well as in adults.
Research and advances has resulted in development of the best combination of chemotherapy that has improved the cure rate, especially in children, to almost 70 to 80%.
What is ALL?
Acute Lymphoblastic Leukemia is a form of blood cancer that is characterized by the abnormal proliferation of the lymphoblasts in the bone marrow and the lymph. ALL has the ability to evolve over a short period of time.
'Acute' refers to the fact that:
• The disease appears suddenly,
• Is fast- developing, and
• May quickly spread to other vital organs.
In a healthy individual, the T- cells and B- cells are the two different types of lymphocytes that produce antibodies to fight infections. These lymphocytes are distributed in the blood, lymph nodes, and spleen.
In patients with ALL, the lymphocytes remain immature and are referred to as lymphoblasts. These immature cells rapidly proliferate and outnumber other blood cells in the blood, bone marrow, and lymph tissue.
Microscopic view of Acute Lymphoblastic Leukemia
In the majority of ALL cases (85%), the B-cell lymphocytes are affected, while in the rest, the T-cells are altered.
ALL is fatal if left untreated and therefore requires immediate attention. Certain varieties of acute leukemia respond favorably to treatment and several affected individuals are successfully cured. However, there are certain types that do not have a pleasing prognosis.
What is new in Acute Lymphoblastic Leukemia?
1. Chemotherapy-associated Neurocognitive Side Effects Found in Leukemia PatientsProblems with attention, organization and related neurocognitive skills were found develop in the long run, if the young patients who had Leukemia were treated with methotrexate therapy in childhood, finds a new study. Read More..
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2. Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med 1998; 339: 605-615.
3. Gurney JG, Severson RK, Davis S, Robinson L. Incidence of cancer in children in the United States. Cancer 1995; 75: 2186-2195.
4. Young J, Gloeckler RL, Silverberg E, Horm J, Miller R. Cancer incidence, survival and mortality for children younger than age 15 years. Cancer 1986; 58: 598-602.
Latest Publications and Research on Acute Lymphoblastic LeukemiaThe MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. - Published by PubMed
Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia; Current Evidence, and Improving Outcomes Going Forward. - Published by PubMed
Clinical characteristics and analysis of treatment result in children with Ph-positive acute lymphoblastic leukaemia in Poland between 2005 and 2017. - Published by PubMed
Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives. - Published by PubMed
Contributions of a regional approach to document hematologic disease in Mexico: a 10-year experience in an open population. - Published by PubMed