About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Working Night Shifts may Affect Our Body in the Long Run

by Rishika Gupta on May 9, 2018 at 3:56 PM
Font : A-A+

 Working Night Shifts may Affect Our Body in the Long Run

Most our Genes can't adapt to new eating and sleeping patterns which are general in working On night shift, finds a new study. The findings of this study are published in the Journal of Proceedings of the National Academy of Sciences.

In a study published in the Proceedings of the National Academy of Sciences, Laura Kervezee, Marc Cuesta, Nicolas Cermakian and Diane B. Boivin, researchers at the DMHUI (CIUSSS de l'Ouest-de-l'Île-de-Montréal), were able to show the impact that a four-day simulation of night shift work had on the expression of 20,000 genes.

Advertisement


"We now better understand the molecular changes that take place inside the human body when sleeping and eating behaviors are in sync with our biological clock. For example, we found that the expression of genes related to the immune system and metabolic processes did not adapt to the new behaviors," says Dr. Boivin, Director of the Centre for Study and Treatment of Circadian Rhythms and a full professor at McGill University's Department of Psychiatry.

It is known that the expression of many of these genes varies over the course of the day and night. Their repetitive rhythms are important for the regulation of many physiological and behavioral processes. "Almost 25% of the rhythmic genes lost their biological rhythm after our volunteers were exposed to our night shift simulation. 73% did not adapt to the night shift and stayed tuned to their daytime rhythm. And less than 3% partly adapted to the night shift schedule," adds Dr. Cermakian, Director of the Laboratory of Molecular Chronobiology at the DMHUI and a full professor at McGill University's Department of Psychiatry.
Advertisement

Health problems ahead?

For this study, eight healthy volunteers were artificially subjected to a five-day schedule simulating night shift work. In a time-isolation room, they were deprived of any light or sound cues characteristic of the time of day and were not allowed to use their phones or laptops. The first day the participants slept during their normal bedtimes. The four following days were "night shifts": the volunteers remained awake during the night and slept during the day.

On the first day and after the last night shift, the team collected blood samples at different times for a period of 24 hours. Laura Kervezee, a postdoctoral fellow on Boivin's team, then measured the expression of more than 20,000 genes using a technique called transcriptomic analysis and assessed which of these genes presented a variation over the day-night cycle.

"We think the molecular changes we observed potentially contribute to the development of health problems like diabetes, obesity, cardiovascular diseases more frequently seen in night-shift workers on the long term," explains Dr. Boivin. However, she adds this will require further investigations.

As the study was conducted under highly controlled conditions in the laboratory, future research should extend these findings by studying the gene expression of actual night shift workers whose physical activity, food intake and timing of sleep might differ from one another. This could also be applied to other people that are at risk of experiencing biological clock misalignment such as travelers crossing time zones on a frequent basis.

Around 20% of the workforce in Canada, the United States, and Europe is involved in shift work.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Healthy Living 

Recommended Reading
Night Shift Workers At Higher Risk Of Stroke Due To Altered Body’s Internal Clock
Altering our internal clocks exacerbates inflammatory responses that lead to the development of ......
Night Shift Workers At Higher Risk For Type 2 Diabetes
Night shift workers are at an increased risk for developing diabetes, as they have trouble ......
Breast Cancer Risk Not Higher Among Women Who Work Night Shifts
The incidence of breast cancer risk was not higher among women working night shift, as previously .....
UK Witnesses Rise In Number Of Employees Working In Night Shifts
The number of women working night shifts has increased at a faster rate by 12 percent since 2007, .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use