About Careers MedBlog Contact us

Women With Atypical Hyperplasia at Higher Risk of Breast Cancer

by Dr. Trupti Shirole on January 2, 2015 at 12:11 PM
Font : A-A+

 Women With Atypical Hyperplasia at Higher Risk of Breast Cancer

Women with atypical hyperplasia (also known as atypia) are at higher risk of developing breast cancer in future than previously thought, according to a Mayo clinic study.

The study found that hundreds of women with these benign lesions indicate that their absolute risk of developing breast cancer grows by over 1 percent a year; and five years later, 7 percent of these women had developed the disease; while the number had increased to 13 percent after 10 years; and 30 percent women had breast cancer after 25 years. The Mato clinic findings have been validated by researchers at Vanderbilt University using biopsies from a separate cohort of women with atypia. Both studies revealed that at 25 years following biopsy, 25 to 30 percent of these women had developed breast cancer.


Researchers were also able to give an accurate estimate of risk by incorporating information from a patient's pathology specimen. They found that as the extent of atypical hyperplasia in a biopsy increased, as measured by the number of separate atypia lesions or foci, so did the woman's risk of developing breast cancer. For example, at 25 years post-biopsy, 47 percent women with three or more atypia lesions in the biopsy had developed breast cancer, compared to only 24 percent of women with one focus.

The findings could benefit more than 100,000 women diagnosed each year with atypical hyperplasia. The research team recommends that women with atypical hyperplasia be recognized as having significantly increased lifetime risk of breast cancer and thus be candidates for intense screening with MRI. Also, they can be given anti-estrogen medications like tamoxifen which lowers the risk of breast cancer by 50 percent or more in women with atypia.

The study has been published in the Journal of Medicine.

Source: Medindia


Recommended Reading

Latest Cancer News

Cancer Drugs to be Tested in Orbit During American Private Astronaut Mission
The mission of Axiom Space incorporated numerous experiments focusing on human stem cell aging, inflammation, and cancer within the laboratory situated in the low Earth orbit.
 Hydrogen Sulfide Makes Cancer Cells More Sensitive to Photothermal Therapy
Providing a sustained supply of hydrogen sulfide to cancer cells, could be a remodeling strategy to improve photothermal therapy efficacy while minimizing side effects.
Hidden Influence of Gut Microbiome on Early-Onset Colorectal Cancer
Colon cancer's hidden link revealed in microbiome study.
Telephone-based Weight Loss Program Helps Breast Cancer Patients Shed Pounds
Breast cancer patients in the obese or overweight category can greatly benefit from a telephone-based weight management program in achieving significant weight loss.
 Tobacco Use Among Cancer Patients Likely to Increase Symptom Burden
A new study assessed the association of cigarette smoking and vaping on cancer-related symptom burden (fatigue, pain, emotional problems) and quality of life.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Women With Atypical Hyperplasia at Higher Risk of Breast Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests