About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Why Lack of Sleep Shuts Down the Brain of Some but Not All

by Chrisy Ngilneii on June 4, 2018 at 5:41 PM
Font : A-A+

Why Lack of Sleep Shuts Down the Brain of Some but Not All

Sleeplessness affects the functioning of the brain differently for everyone.

According to a new study at the University of Pennsylvania, the key to predicting how someone is affected by sleep loss may be found in microRNAs.

Advertisement


MiRNAs are small non-coding RNAs and are key regulators of gene expression, which guides information in a gene to be made into a functional protein. MiRNAs typically repress expression of their target messenger RNAs, preventing translation into proteins.

This study is the first to find that microRNAs in the blood are changed by total sleep deprivation (TSD) for 39 hours, and by psychological stress, and can predict the resulting cognitive performance in adults. The authors say the findings can be used to identify who is most at risk for the negative effects of sleep deprivation, and thus should receive medical assistance to prevent those effects.
Advertisement

In the study, 32 healthy adults participated in a five-day experiment consisting of two, 8-hour baseline nights, followed by 39 hours of total sleep deprivation (TSD), in which they were not allowed to sleep, and followed by two, 8-to-10-hour recovery nights.

Subjects underwent testing for attention, memory, and cognitive throughput, i.e., how fast and accurate the brain performs of cognitive tests, were administered throughout the experiment to measure cognitive performance. Blood samples were taken at six-time points and miRNAs from plasma were analyzed.

Compared to the pre-study time point, 10 miRNAs showed changes in their expression level in subjects who experienced TSD alone compared to 18 miRNAs with expression level changes in these subjects when they experienced TSD and psychological stress.

Notably, from the miRNA blood sample taken before the study began, 14 miRNAs reliably predicted behavioral attention performance during TSD, 7 miRNAs reliably predicted cognitive throughput performance during TSD and 10 miRNAs reliably predicted memory performance.

"These findings show for the first time that miRNAs can track responses to total sleep deprivation and its detrimental combination with psychological stress and predict robust individual differences in various types of cognitive performance," said senior author Namni Goel, Ph.D, an associate professor of Psychology in Psychiatry. "As such, miRNAs are viable biomarkers of sleep deprivation, psychological stress, and cognitive vulnerability in humans and can be used to identify individuals ahead of time who are in need of countermeasures or interventions such as caffeine or naps to mitigate or prevent impairments associated with insufficient sleep."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping  A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Snoring Parkinsons Disease Sleep Disorder : Restless Legs Syndrome Sleep Disorder: Sleepwalking Parkinsons Disease Surgical Treatment Periodic Limb Movement Disorder REM Behavior Disorder Sleep Disturbances In Women Sleep Insomnia 

Recommended Reading
Sleep Disturbances In Women
The physical, emotional and hormonal changes that occur in women during puberty, menstrual cycle, .....
Insomnia Symptom Evaluation
Insomnia may be due to physiological, psychological, physical or environmental factors. Insomnia ......
Sleep Disorder: Sleepwalking
Sleepwalking or "Somnambulism," is a type of parasomnia and has medico-legal implications...
Sleep Deprivation can lead to a Host of Serious Health Problems
Whether you have trouble sleeping or trouble staying asleep, it's important that you address the ......
Insomnia
Difficulty in initiating and maintaining sleep is known as insomnia. It is a symptom that occurs due...
Parkinsons Disease
Parkinsons disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Periodic Limb Movement Disorder
Periodic limb movement disorder (PLMD) is a sleep disorder which causes repetitive cramping or jerki...
REM Behavior Disorder
REM Behavior Disorder (RBD) is a sleep disorder in which the person acts out dramatic or violent dre...
Sleep
Sleep is a behavioral state of restricted physical activity. It is controlled by our internal biolo...
Sleep Disorder : Restless Legs Syndrome
Restless legs syndrome (RLS) causes - An urge to move, usually due to uncomfortable sensations that...
Snoring
Turbulent airflow causes tissues of the nose and throat to vibrate and the noise produced by these v...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)