About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Vitamin B12 Mapped in Action

by Kathy Jones on April 1, 2012 at 9:57 PM
Font : A-A+

 Vitamin B12 Mapped in Action

Scientists have revealed that vitamin B12 morphs into a gymnast as soon as it gets into the body. This is because they have mapped its twisting and turning as part of a crucial reaction called methyl-transfer.

University of Michigan Health System and MIT scientists captured these contorting images in 3-D for the first time, by aiming intense beams of X-rays at crystallized forms of the protein complex and painstakingly determining the position of every atom inside.

Advertisement

Methyl-transfer is a reaction vital both in human cells and in a slightly different way, in the cells of bugs that consume carbon dioxide and carbon monoxide, the journal Nature reports, citing a statement from the varsity and MIT.

"Without this transfer of single carbon units involving B12, and its partner B9 (otherwise known as folic acid), heart disease and birth defects might be far more common," explained Stephen W. Ragsdale, Michigan professor of biological chemistry, who led the study.
Advertisement

"Similarly, the bacteria that rely on this reaction would be unable to consume carbon dioxide or carbon monoxide to stay alive - and to remove gas from our guts or our atmosphere. So it's important on many levels," he added.

Researchers used B12 complexes from another type of CO2-munching bugs found in the murky pond bottoms for experiments.

These 3-D images show the intricate molecular juggling needed for B12 to serve its biologically essential function. Ragsdale notes that this methyl-transfer reaction is crucial to human health.

Vitamin B12, also called cobalamine and one of the eight B vitamins, is water-soluble, playing a key role in the normal functioning of the brain and nervous system and for blood formation.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Vitamin-F Diet for Anemia in Pregnancy Vitamin B12 - An Essential Vitamin Undetected Nutrient Deficiencies: the Cause of Ill Health 

Most Popular on Medindia

Diaphragmatic Hernia Drug - Food Interactions Find a Doctor Indian Medical Journals Calculate Ideal Weight for Infants Blood Pressure Calculator Vent Forte (Theophylline) Color Blindness Calculator The Essence of Yoga A-Z Drug Brands in India
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Vitamin B12 Mapped in Action Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests