Medindia
Advertisement

UTIs Could be Non-antibiotically Treated Using Zinc

by Mohamed Fathima S on March 10, 2019 at 2:07 PM

UTIs Could be Non-antibiotically Treated Using Zinc
Non-antibiotic strategies for treating bacterial infections such as urinary tract infections (UTIs) could include zinc, reveals a study. The mineral could treat UTIs, which is one of the most commonly occurring bacterial infections that affect 150 million cases every year. UTIs can lead to severe conditions like kidney infections and sepsis.

A team of cross-institutional University of Queensland researchers led by Professor Matt Sweet, Professor Mark Schembri and Dr Ronan Kapetanovic examined how our immune system uses zinc to fight uropathogenic Escherichia coli (UPEC) - the major cause of UTIs.
Advertisement


Dr Kapetanovic, from UQ's Institute for Molecular Bioscience (IMB), said researchers already knew that zinc was toxic to bacteria.

"We confirmed by direct visualization that cells in our immune system known as macrophages deploy zinc to clear bacterial infections," Dr Kapetanovic said.
Advertisement

They also discovered that UPEC has a two-pronged strategy to survive the body's immune response.

"We found that, compared to non-pathogenic bacteria, UPEC can evade the zinc toxicity response of macrophages, but these bacteria also show enhanced resistance to the toxic effects of the zinc.

"These findings give us clues to how our immune system battles infections, and also potential avenues to develop treatments, such as blocking UPEC's escape from zinc to make it more sensitive to this metal.

"Treatment strategies that don't use antibiotics have the advantage of bacteria not developing resistance; if we can reprogram our immune cells to make them stronger, or change the way they respond to bacteria, we would be better equipped to fight superbugs."

UQ's School of Chemistry and Molecular Biosciences Dr Minh Duy Phan said the study also identified the full set of UPEC genes that provide protection against zinc toxicity.

"This knowledge provides another potential avenue for developing antimicrobial agents for the treatment of UTIs", Dr Phan said.

IMB PhD student Miss Claudia Stocks said the methods the team used could be applied to the study of other bacterial diseases, not just UTIs.

"Macrophages deploy zinc toxicity against several types of bacteria, such as Mycobacterium tuberculosis, Salmonella and Streptococcus, that aren't necessarily being cleared from the body by normal mechanisms," Miss Stocks said.

"We developed zinc sensors that can be adapted to study different types of bacteria, bringing us closer to understanding our immune system better and creating therapies for a range of infectious diseases."

The research was published in Proceedings of the National Academy of Sciences USA and funded by Australia's National Health and Medical Research Council, the Australian Research Counciland Australian Cancer Research Foundation.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Minerals: Not Just the Gold And Silver Foods High in Zinc Urinary Tract Infection During Pregnancy 

Recommended Reading
Cystoscopy
Cystoscopy is a procedure wherein the urologist visualizes the lining of the urinary bladder and ......
Alkaptonuria (Black Urine Disease)
Alkaptonuria or black urine disease is an inherited disorder where a chemical called homogentisic .....
Kidney Stones during Pregnancy
Urolithiasis is a condition where stones ranging from microscopic sizes to large ones are found in ....
Incontinence-Involuntary Loss of Urine-An impact on the daily life solution
Unintentional loss of urine has multiple implications to the sufferer. Urinary Incontinence has ......
Foods High in Zinc
Zinc is needed in small amounts every day for good health. It is very important for proper functioni...
Minerals: Not Just the Gold And Silver
Minerals are important for our body and are helpful to keep the vital organs functioning. Hence we s...
Urinary Tract Infection During Pregnancy
Urinary tract infections are caused mainly by E.coli and can occur during pregnancy. If not treate...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use