About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Unique Immune Proteins Needed for HIV to Infiltrate Blood-Brain Barrier

by Himabindu Venkatakrishnan on February 3, 2015 at 6:51 PM
Font : A-A+

 Unique Immune Proteins Needed for HIV to Infiltrate Blood-Brain Barrier

HIV requires unique immune proteins, called 'mature monocytes', to enter the brain, crossing the brain's blood-brain barrier, reveals a new study.

Although it was known that HIV can enter the brain early during infection, causing inflammation and memory/cognitive problems, exactly how this occurs has been largely unknown. The new study solves this mystery by showing that HIV relies on proteins expressed by a type of immune cell, called "mature monocytes," to enter the brain.

Advertisement

These proteins are a likely drug target for preventing HIV from reaching brain cells. Although not a direct focus of this research, these proteins might also shed light on novel mechanisms for helping drugs penetrate the blood-brain barrier.

The researchers found that the mature monocytes had an increased ability to enter into the brain due to the unique proteins they expressed, which could lead to HIV infecting the brain.
Advertisement

John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, said that Monocytes are normal part of the immune system's defense against viruses, but these cells have also been known to act like "Trojan horses" and carry viruses from the site of initial infection to other parts of the body.

Identifying how these cells facilitate HIV entry into the brain might provide new treatment opportunities not only for HIV but other neurological diseases, he further added.

The study is published in the Journal of Leukocyte Biology.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Unique Immune Proteins Needed for HIV to Infiltrate Blood-Brain Barrier Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests