The committee voted against any harsh measures, recommending only that information from two neutral clinical trials with the drugs be added to the drugs' labels and rejected withdrawal or new restrictions.
The trials on two DPP-4 inhibitors, saxagliptin and alogliptin, concluded that the results show no evidence of either cardiovascular benefit or harm. DPP-4 inhibitors reduce glucagon and blood glucose levels and increases incretin levels, which increase insulin secretion and decreases gastric emptying.
Panel members called on the FDA to get companies to study the heart failure question more closely. Without any evidence of cardiovascular benefit, the panelist said, "the diabetes community needs to demonstrate that lowering HbA1c is beneficial."