About My Health Careers Internship MedBlogs Contact us

Trials of New Blood Clot Buster Technique to Be Led by Indian Origin Researcher

by Rajashri on September 17, 2008 at 5:15 PM
Font : A-A+

 Trials of New Blood Clot Buster Technique to Be Led by Indian Origin Researcher

The first major trial of a catheter-based treatment for deep vein thrombosis is due to be led by an Indian-origin researcher. The study will evaluate the use of clot-dissolving drugs in combination with clot removal devices to prevent post-thrombotic syndrome in patients with DVT.

Dr. Suresh Vedantham, an interventional radiologist, hopes that the results of the National Institutes of Health's National Heart, Lung and Blood Institute (NHLBI)-funded ATTRACT trial will revolutionise the way DVT is treated in the country.


"The ATTRACT trial could fundamentally shift the 50-year-old DVT treatment paradigm to one that includes interventional clot removal as an essential element of standard DVT care," said Vedantham, who is an associate professor at the Washington University School of Medicine's Mallinckrodt Institute of Radiology in St. Louis.

"By funding this study, the NHLBI has clearly recognized the strong potential of interventional radiology clot removal treatments for DVT to improve public health," Vedantham added.

ATTRACT is a multicenter, randomized trial "that will definitively determine if the newest clot-busting treatment (pharmacomechanical catheter-directed thrombolysis or PCDT) prevents post-thrombotic syndrome in patients with DVT," the expert said.

He has revealed that PCDT combines the use of a clot-dissolving drug with a catheter-mounted miniature clot removal device, allowing an interventional radiologist to break up the clot and remove it from the vein, restoring blood flow.

"PTS is a serious complication of DVT that is under recognized and potentially preventable if we are able to dissolve the clots early, before permanent damage to the vein occurs. Established PTS is a lifelong, irreversible condition for which there are no consistently effective treatments. Its prevention is extremely important; however, physicians have historically neglected the prevention of PTS," said Vedantham.

"The groundbreaking combination of clot-busting drugs with innovative device technology-pioneered by interventional radiologists-now enables clot removal in a safer and more efficient manner, often in a single procedure session. These advances will greatly increase the use of interventional DVT treatments," he added.

Dr. Michael Darcy, chair of the board of directors for SIR Foundation, a scientific foundation dedicated to fostering research and education in interventional radiology, said: "This research is critical. The Society of Interventional Radiology Foundation initiated a DVT research consensus panel four years ago, bringing together clinicians and scientists from all disciplines and from all settings-academia, private practice, government and industry-and determining the need for the ATTRACT trial."

DVT is the formation of a blood clot, known as a thrombus, in a deep leg vein. This can be a very serious condition that often causes permanent damage to the leg, known as post-thrombotic syndrome.

Early treatment with blood thinners can prevent a life-threatening pulmonary embolism, but blood thinners do not dissolve the existing clot, which remains in the leg.

Though clots in many patients slowly dissolve over time, often the vein wall and vein valves become irreversibly damaged in the process.

"PTS develops as a direct result of having the blood clot stay in the vein. The blood clot continues to block the vein and permanently damages its one-way valves, resulting in the pooling of blood in the leg, chronic leg pain, swelling and fatigue and sometimes skin ulcers. It's logical that immediate clot removal will prevent PTS," said Vedantham.

The ATTRACT trial, which begins later this year, will assess the presence and severity of PTS, quality of life, relief of pain and swelling, safety and costs.

At least 28 U.S. clinical centres will enrol 692 patients and monitor their health for two years, said Vedantham.

Source: ANI

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Anticoagulants von Willebrand Disease Deep Vein Thrombosis Pulmonary Embolism Hemophilia Blood Clots Blood in Stools - Symptom Evaluation Bombay Blood Group Beauty Parlor Stroke Syndrome 

Recommended Reading
Blood Group Calculator
Blood group calculator gives you a detailed outlook of various blood groups, and also calculates ......
Beware of Leg Clots, Warns US Surgeon General
Beware of leg clots, US surgeon general has warned. Dangerous blood clots may affect up to 600,000 ....
Study Says Migraine Sufferers More Prone to Blood Clots
A study published in the September 16, 2008, issue of Neurology says that migraine sufferers may ......
Anticoagulants prevent the clotting of blood in our body. They are administered orally or via ......
Beauty Parlor Stroke Syndrome
Beauty parlor stroke syndrome is a form of vertebrobasilar insufficiency that causes symptoms of mil...
Blood Clots
An abnormal blood clot forms when there is damage to the lining of an artery or stagnation of blood ...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Deep Vein Thrombosis
A blood clot (thrombus) in the deep venous system of the leg leads to deep vein thrombosis (DVT). DV...
Hemophilia is a rare single gene, X- linked disorder, which tends to run in families....
Pulmonary Embolism
Pulmonary embolism (PE) is a complication that results from a block in the main artery supplying the...
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
von Willebrand Disease
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use