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Traumatic Brain Injury Linked To Premature Death And Long-Term Psychological Outcomes

by Dr. Meenakshy Varier on August 24, 2016 at 11:23 AM
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Traumatic Brain Injury Linked To Premature Death And Long-Term Psychological Outcomes

Traumatic brain injury (TBI) during youth is associated with elevated risks of impaired adult functioning, according to a longitudinal study published in†PLOS Medicine.

The study, conducted by Seena Fazel of the University of Oxford, United Kingdom, and colleagues, demonstrates that children and adolescents experiencing even milder forms of TBI (including concussion) may have reduced longevity and significant psychosocial problems in adulthood.


TBI constitutes the leading cause of morbidity and mortality in individuals under the age of 45 yea globally. However, research on the long-term health of people with TBI has commonly addressed more severe injuries and medical diagnoses.

To uncover broader risks associated with TBI, Fazel and colleagues compared premature mortality and long-term psychosocial outcomes between the roughly 100,000 people born in Sweden between 1973 and 1985 who sustained at least one TBI before age 25 years, and their unaffected siblings, who were followed up until age 41.

The researchers found that TBI consistently predicted later risk of premature mortality, psychiatric inpatient admission, psychiatric outpatient visits , disability pension, welfare recipiency and low educational attainment in the sibling-comparison analyses, and the effects were stronger for those with greater injury severity, recurrence, and older age at first injury.

The datasets used may include some misclassification, and despite the sibling-comparison design the associations may be confounded by shared factors other than TBI.

Nonetheless, Fazel and colleagues' estimates are likely conservative and suggest that the public health benefits of preventing TBI include longevity and psychosocial outcomes.

The authors state, "[s]ervices should consider how to routinely and systematically review these children [with TBI] on a regular basis to allow the subtle but important neurological, cognitive, and psychiatric consequences of TBI to be identified."

In an accompanying Perspective, Donald Redelmeier and Sheharyar Raza discuss the study design, limitations, and theories for the mechanism by which TBI could cause adverse long-term psychosocial consequences.

Source: Medindia

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