Medindia LOGIN REGISTER
Medindia
Advertisement

To Prevent Most Common Type of Heart Disease, Scientists Alter Fat Metabolism in Animals

by Dr. Enozia Vakil on April 28, 2014 at 11:12 PM
 To Prevent Most Common Type of Heart Disease, Scientists Alter Fat Metabolism in Animals

With a view to prevent the development of atherosclerosis, scientists have found a way to block abnormal cholesterol production, transport and breakdown successfully.

Lead investigator Subroto Chatterjee, Ph.D., a cardio-metabolic expert at the Johns Hopkins Children's Center Current asserted that cholesterol-lowering medications tackled the issue on a single front either by blocking cholesterol synthesis or by preventing the body from absorbing too much of it, but atherosclerosis was a multi-factorial problem that required hitting the abnormal cholesterol cycle at many points.

Advertisement

The Johns Hopkins team used an existing man-made compound called D-PDMP to block the synthesis of the GSL molecule, and as a result it prevented the development of heart disease in mice and rabbits fed a high-fat, cholesterol-laden diet.

The findings reveal that D-PDMP appears to work by interfering with a constellation of genetic pathways that regulated the fat metabolism on multiple fronts from the way cells derived and absorbed the cholesterol from food in a way that cholesterol was transported to tissues and organs and was then broken down by the liver and excreted from the body.
Advertisement

The experiments showed that treatment with D-PDMP led to a drop in the animals' levels of bad cholesterol or low-density lipoprotein, LDL and a drop in oxidized LDL, a particularly virulent form of fat that formed when LDL encountered the free radicals.

The results also showed that a there was a surge in good cholesterol or high-density lipoprotein, HDL, known to counteract the effects of LDL by mopping it up and a significant drop in triglycerides, that was another type of plaque-building fat.

The study has been published in the journal Circulation.

Source: ANI
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

AI Shows Promise in Identifying ADHD
The AI method shows promise in identifying imaging biomarkers for diagnosing ADHD.
Life Expectancy Gap for Autistic Individuals Revealed
Diagnosed autistic individuals showed increased premature mortality in the UK, highlighting urgent needs to address associated inequalities.
Exploring How Hearing Impairment Shapes Dementia Risk
Study reveals a correlation between hearing impairment and distinct brain region variances, contributing to dementia.
Coffee and its Role in Neurodegenerative Disorders
Financial impact of caring for individuals with neurodegenerative disorders reaches hundreds of billions annually in the United States.
Healthcare Industry Struggles With Tech Skills Shortage
Experts emphasize that addressing the skills gap demands immediate attention and innovative solutions, including education, re-training, and significant time investment.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

To Prevent Most Common Type of Heart Disease, Scientists Alter Fat Metabolism in Animals Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests