With a view to prevent the development of atherosclerosis, scientists have found a way to block abnormal cholesterol production, transport and breakdown successfully.
Lead investigator Subroto Chatterjee, Ph.D., a cardio-metabolic expert at the Johns Hopkins Children's Center Current asserted that cholesterol-lowering medications tackled the issue on a single front either by blocking cholesterol synthesis or by preventing the body from absorbing too much of it, but atherosclerosis was a multi-factorial problem that required hitting the abnormal cholesterol cycle at many points.
Scientists Find New Way to Prevent Heart Attack and Stroke
Scientists at Johns Hopkins have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis.
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The Johns Hopkins team used an existing man-made compound called D-PDMP to block the synthesis of the GSL molecule, and as a result it prevented the development of heart disease in mice and rabbits fed a high-fat, cholesterol-laden diet.
The findings reveal that D-PDMP appears to work by interfering with a constellation of genetic pathways that regulated the fat metabolism on multiple fronts from the way cells derived and absorbed the cholesterol from food in a way that cholesterol was transported to tissues and organs and was then broken down by the liver and excreted from the body.
![Heart Attack and Stroke Risk may be Detected Via New Ultrasound Device]( "Heart Attack and Stroke Risk may be Detected Via New Ultrasound Device")
An ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke has been developed.
The experiments showed that treatment with D-PDMP led to a drop in the animals' levels of bad cholesterol or low-density lipoprotein, LDL and a drop in oxidized LDL, a particularly virulent form of fat that formed when LDL encountered the free radicals.
The results also showed that a there was a surge in good cholesterol or high-density lipoprotein, HDL, known to counteract the effects of LDL by mopping it up and a significant drop in triglycerides, that was another type of plaque-building fat.
The study has been published in the journal Circulation.
Source: ANI
Heart Attack and Stroke Risk may be Detected Via New Ultrasound Device
An ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke has been developed.
Advertisement
The experiments showed that treatment with D-PDMP led to a drop in the animals' levels of bad cholesterol or low-density lipoprotein, LDL and a drop in oxidized LDL, a particularly virulent form of fat that formed when LDL encountered the free radicals.
The results also showed that a there was a surge in good cholesterol or high-density lipoprotein, HDL, known to counteract the effects of LDL by mopping it up and a significant drop in triglycerides, that was another type of plaque-building fat.
The study has been published in the journal Circulation.
Source: ANI
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