The mystery behind the continuously ticking human biological clock seems to have been solved by biologists from the University of Pennsylvania.
Richard Schultz and Michael Lampson showed that this basic fact of reproductive life is most likely caused by weakened chromosome cohesion. It causes an increase in aneuploidy, the term for an abnormal number of chromosomes during reproductive cell division.
Ageing and Sleep
Sleep is a barometer of good health in the elderly. Sleep problems in the elderly are controlled by various external and internal factors.
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With age, egg cells experience decreasing amounts of a protein, REC8 that is essential for chromosomes to segregate correctly during the process that forms an egg.
Because cohesion in these cells is established during foetal development, and must remain functional up to 50 years or so in humans, defective cohesion is a good candidate for a process that might fail with increasing maternal age.
![Genetic Test to Predict Woman]( "Genetic Test to Predict Woman")
A new genetic test that claims to predict the timeline of a woman's biological clock might go on sale as early as next year, scientists have revealed.
During these studies, the scientists noticed that sister kinetochores - the protein structures that mark the site where a chromosome pair is split during cell division - are farther apart in metaphase II eggs from older mice at 16 to 19 months of age compared to eggs from young mice of 6 to 14 weeks of age, a finding that drew their attention to explore reduced cohesion as a primary source for age-related aneuploidy.
The study appeared in the journal Current Biology.
Source: ANI
Genetic Test to Predict Woman's Biological Clock Timeline
A new genetic test that claims to predict the timeline of a woman's biological clock might go on sale as early as next year, scientists have revealed.
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During these studies, the scientists noticed that sister kinetochores - the protein structures that mark the site where a chromosome pair is split during cell division - are farther apart in metaphase II eggs from older mice at 16 to 19 months of age compared to eggs from young mice of 6 to 14 weeks of age, a finding that drew their attention to explore reduced cohesion as a primary source for age-related aneuploidy.
The study appeared in the journal Current Biology.
Source: ANI
Scientists Find Switch to Reverse Biological Clock
Researchers from the University of California at Berkeley have stumbled upon a chemical 'switch' that can reverse the biological clock.
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 Body's Biological Clock Influences Cancer ChemotherapyThe circadian clock is found to pose a major impact on the response to cancer chemotherapy, based on the nucleotide excision repair mechanism of the cell. | Advertisement
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