A risk factor for stroke is the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Studies have report a higher C677T homozygosity frequency in Chinese than in Europeans. Usually, the detection of genetic diseases is rather complicated on a large scale owing to the invasive sampling and a cumbersome DNA extraction process. In a study by Dr. Li Yi and team from Peking University Shenzhen Hospital in China, DNA from stroke patients and healthy controls was extracted from the saliva using a magnetic nanoparticles-based method and from the blood using conventional methods. Real-time PCR results revealed that the C677T polymorphism was genotyped by PCR using DNA extracted from both saliva and blood samples. The genotype results were confirmed by gene sequencing, and results for saliva and blood samples were consistent. Therefore, this noninvasive magnetic nanoparticles-based method using saliva samples could be used to screen for the MTHFR C677T polymorphism in target populations. This study was published in the Neural Regeneration Research (Vol. 8, No. 32, 2013). Source: Eurekalert << Researchers Combine Cell Transplantation And Gene Therapy F... Need a Drink After A Tiring Day At Work? Have A Robotic Bar... >> Recommended Reading Largest-ever Database on Cancer Genetics Released in Public Domain Database on cancer-related genetic variations has been released by National Cancer Institute. READ MORE Genetics of Depression: In Pursuit of Perfect Treatment There is a complicated nexus between genes, environment and drug response. Studies in genetic variability would help to understand drug response in the mentally ill who are drug-resistant. READ MORE Optogenetics and Its Clinical Applications Light controlled neurons by genetically encoded molecules called opsins is what optogenetics is about. A new science that could revolutionize diagnosis and treatment. READ MORE Genetics May More Accurately Help in Predicting Psoriasis A recent study depicted that it is possible to use a set of SNP data for psoriasis prediction. READ MORE Congenital Heart Disease Heart diseases that are present at birth are called “ Congenital heart diseases”. READ MORE DNA Finger Printing DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, identity thefts, legal suits and terrorism cases. READ MORE Genetic Testing of Diseases Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques READ MORE Hyperventilation Hyperventilation occurs when a person breathes in excess to the body’s requirement. READ MORE Mitral Valve Stenosis And Mitral Valve Replacement Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or the leakage (regurgitation). READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Stroke Stroke can cause permanent disability and it is important to recognize its early warning signs to stop its progress. Early warning signs of stroke include sudden weakness of facial muscles. READ MORE Most Popular on Medindia The Essence of Yoga Calculate Ideal Weight for Infants Pregnancy Confirmation Calculator More News on: DNA Finger PrintingBell´s PalsyDiet Lifestyle and Heart DiseaseMitral Valve Stenosis And Mitral Valve ReplacementCongenital Heart DiseaseStress and the Gender DivideGenetic Testing of DiseasesStroke FactsStrokeHyperventilation
A risk factor for stroke is the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Studies have report a higher C677T homozygosity frequency in Chinese than in Europeans. Usually, the detection of genetic diseases is rather complicated on a large scale owing to the invasive sampling and a cumbersome DNA extraction process. In a study by Dr. Li Yi and team from Peking University Shenzhen Hospital in China, DNA from stroke patients and healthy controls was extracted from the saliva using a magnetic nanoparticles-based method and from the blood using conventional methods. Real-time PCR results revealed that the C677T polymorphism was genotyped by PCR using DNA extracted from both saliva and blood samples. The genotype results were confirmed by gene sequencing, and results for saliva and blood samples were consistent. Therefore, this noninvasive magnetic nanoparticles-based method using saliva samples could be used to screen for the MTHFR C677T polymorphism in target populations. This study was published in the Neural Regeneration Research (Vol. 8, No. 32, 2013). Source: Eurekalert << Researchers Combine Cell Transplantation And Gene Therapy F... Need a Drink After A Tiring Day At Work? Have A Robotic Bar... >> Recommended Reading Largest-ever Database on Cancer Genetics Released in Public Domain Database on cancer-related genetic variations has been released by National Cancer Institute. READ MORE Genetics of Depression: In Pursuit of Perfect Treatment There is a complicated nexus between genes, environment and drug response. Studies in genetic variability would help to understand drug response in the mentally ill who are drug-resistant. READ MORE Optogenetics and Its Clinical Applications Light controlled neurons by genetically encoded molecules called opsins is what optogenetics is about. A new science that could revolutionize diagnosis and treatment. READ MORE Genetics May More Accurately Help in Predicting Psoriasis A recent study depicted that it is possible to use a set of SNP data for psoriasis prediction. READ MORE Congenital Heart Disease Heart diseases that are present at birth are called “ Congenital heart diseases”. READ MORE DNA Finger Printing DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, identity thefts, legal suits and terrorism cases. READ MORE Genetic Testing of Diseases Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques READ MORE Hyperventilation Hyperventilation occurs when a person breathes in excess to the body’s requirement. READ MORE Mitral Valve Stenosis And Mitral Valve Replacement Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or the leakage (regurgitation). READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Stroke Stroke can cause permanent disability and it is important to recognize its early warning signs to stop its progress. Early warning signs of stroke include sudden weakness of facial muscles. READ MORE Most Popular on Medindia The Essence of Yoga Calculate Ideal Weight for Infants Pregnancy Confirmation Calculator More News on: DNA Finger PrintingBell´s PalsyDiet Lifestyle and Heart DiseaseMitral Valve Stenosis And Mitral Valve ReplacementCongenital Heart DiseaseStress and the Gender DivideGenetic Testing of DiseasesStroke FactsStrokeHyperventilation
